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Cell Transplantation for Ischemic Heart Disease

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Handbook of Cardiac Anatomy, Physiology, and Devices

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Abstract

Recent studies support the notion that cardiomyocyte regeneration may occur during physiological and pathological states in the adult heart. These data highlight the possibilities that myocardial regeneration may occur via cardiomyocyte proliferation and/or differentiation of putative cardiac stem cells. To date, various cell types have been used for cardiac repair, including skeletal myoblasts, bone marrow-derived cells, mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), umbilical cord blood (UCB) stem cells, cardiac stem cells, and embryonic stem cells (ESCs). This chapter will review each of these different stem cell populations in regards to the potential treatment of heart disease. We will examine the in vitro and in vivo animal studies, and then briefly discuss the cell therapy clinical trials that are currently underway for the treatment of ischemic heart disease.

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Abbreviations

CPCs:

Cardiac progenitor cells

EPCs:

Endothelial progenitor cells

ESCs:

Embryonic stem cells

HGF:

Hepatocyte growth factor

hiPSCs:

Human induced pluripotent stem cells

IGF-1:

Insulin-like growth factor

LV:

Left ventricular

MI:

Myocardial infarction

MSCs:

Mesenchymal stem cells

Sca-1:

Stem cell antigen-1

SDF-1:

Stromal cell-derived factor-1

SP:

Side population

UCB:

Umbilical cord blood

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Lillehei Heart Institute, Minneapolis, MN, USA

    Jianyi Zhang MD, PhD & Daniel J. Garry MD, PhD

  2. University of Minnesota, 268 Variety Club Research Center, 401 East River Road, Minneapolis, MN, 55455, USA

    Jianyi Zhang MD, PhD & Daniel J. Garry MD, PhD

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  1. Jianyi Zhang MD, PhD
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  2. Daniel J. Garry MD, PhD
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Correspondence to Jianyi Zhang MD, PhD .

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Editors and Affiliations

  1. B172 Mayo, MMC 195, University of Minnesota Department of Surgery, Minneapolis, Minnesota, USA

    Paul A. Iaizzo

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Zhang, J., Garry, D.J. (2015). Cell Transplantation for Ischemic Heart Disease. In: Iaizzo, P. (eds) Handbook of Cardiac Anatomy, Physiology, and Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-19464-6_40

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