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Animal Models for Cardiac Research

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Handbook of Cardiac Anatomy, Physiology, and Devices

Abstract

The modern era of cardiac surgery is largely considered to have begun in the animal research laboratories. Today, animal models continue to be used for the study of cardiovascular diseases and are required for the preclinical assessment of pharmaceuticals, mechanical devices, therapeutic procedures, and/or continuation therapies. This chapter was written to provide readers and potential investigators with important background information necessary for the process of matching an experimental hypothesis to an animal species that will serve as an appropriate model for studying a specific cardiovascular disease or for testing a given medical device. A review of the current animal models used in cardiac research is provided and arranged by disease state. Critical factors to consider when choosing an appropriate animal model including costs, reproducibility, and degree of similarity of the model to human disease are discussed. Thus, this chapter can be utilized as a practical guide for planning of research protocols.

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Authors and Affiliations

  1. Department of Surgery, University of Minnesota, MMC 195, 420 Delaware St. SE, Minneapolis, MN, 55455, USA

    Nicholas Robinson BVSc (Hons), PhD, DACVP, Laura Souslian MD, Robert P. Gallegos MD, PhD, Andrew L. Rivard MD, Agustin P. Dalmasso MD & Richard W. Bianco

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  1. Nicholas Robinson BVSc (Hons), PhD, DACVP
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  2. Laura Souslian MD
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  3. Robert P. Gallegos MD, PhD
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  4. Andrew L. Rivard MD
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  5. Agustin P. Dalmasso MD
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  6. Richard W. Bianco
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Correspondence to Richard W. Bianco .

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Editors and Affiliations

  1. B172 Mayo, MMC 195, University of Minnesota Department of Surgery, Minneapolis, Minnesota, USA

    Paul A. Iaizzo

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Robinson, N., Souslian, L., Gallegos, R.P., Rivard, A.L., Dalmasso, A.P., Bianco, R.W. (2015). Animal Models for Cardiac Research. In: Iaizzo, P. (eds) Handbook of Cardiac Anatomy, Physiology, and Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-19464-6_27

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