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Amyloid and Related Disorders pp 469–479Cite as

Cutaneous Amyloidosis

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Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

Skin involvement by amyloid commonly indicates a systemic form of amyloidosis, but a localized process may also occur. The spectrum of primary localized cutaneous amyloidosis (PLCA) includes keratinic primary localized amyloidosis (kPLCA), due to deposition of cytokeratins (CKs) and nodular localized primary cutaneous amyloidosis (NLPCA) which is associated with a local B-cell/plasma cell disorder responsible for the local production of amyloidogenic light chains. The distinction between these two skin-restricted forms of amyloidosis relies on the accurate typing of the amyloid deposits. Immunohistochemistry (IHC) and mass spectrometry-based proteomics are fundamental for diagnostic confirmation and provide valuable information regarding the etiology and clinicopathological features of cutaneous amyloidosis.

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Authors and Affiliations

  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Oana Madalina Mereuta MD, PhD

  2. Departments of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Ahmet Dogan MD, PhD

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  1. Oana Madalina Mereuta MD, PhD
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  2. Ahmet Dogan MD, PhD
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Correspondence to Ahmet Dogan MD, PhD .

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Editors and Affiliations

  1. Department of Pathology, Loyola University Medical Center, Maywood, Illinois, USA

    Maria M. Picken

  2. Department of Pathology, LSU Health Shreveport, Shreveport, Louisiana, USA

    Guillermo A. Herrera

  3. Department of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, New York, New York, USA

    Ahmet Dogan

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Mereuta, O.M., Dogan, A. (2015). Cutaneous Amyloidosis. In: Picken, M., Herrera, G., Dogan, A. (eds) Amyloid and Related Disorders. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-19294-9_34

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