Abstract
Biochemical genetic tests and newborn screening tests are considered high-complexity tests. Laboratories that perform these tests must meet more severe regulations for the total testing process in comparison with general laboratories. Moreover, the qualification of laboratory personnel, including training and experience, is a critical factor for ensuring the quality of laboratory test results. In newborn screening for congenital hypothyroidism (CH), the improvement of the analytical and functional sensitivity of TSH assays, as well as the increasing use of the retest at 2–4 weeks of life (serial testing) in preterm or sick newborns, has increased the use of TSH as primary screening test for CH. Although TSH as primary screening test is the most used screening strategy for CH worldwide, other strategies are possible: T4-backup TSH, Tandem T4 and TSH (in all samples),T4-TSH-TBG combined method, Tandem fT4 and TSH
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Corbetta, C., Alberti, L. (2015). Laboratory Aspects in Neonatal Screening of Congenital Hypothyroidism. In: Bona, G., De Luca, F., Monzani, A. (eds) Thyroid Diseases in Childhood. Springer, Cham. https://doi.org/10.1007/978-3-319-19213-0_5
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DOI: https://doi.org/10.1007/978-3-319-19213-0_5
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