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Antitumor Phenylpropanoids

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Bioactive Essential Oils and Cancer

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Abstract

Phenylpropanoids are a class of organic compounds synthesized in plant organisms and is derived from the junction of the phenyl group (aromatic ring) and a three-carbon side chain (propyl group), which is synthesized from phenylalanine in the first step of biosynthesis. The phenylpropanoids are found throughout the plant kingdom, and serve as precursors for a series of natural polymers, which provide protection against ultraviolet light, defense against herbivores and pathogens, and mediate plant–pollinator interactions by pigmentation and floral aroma compounds. In scientific reports, there are diverse biological and/or pharmacological properties attributed to the phenylpropanoids.

In this chapter, data on the antitumor or chemopreventive activities of different phenylpropanoids were described, showing that these substances act by inhibiting or modulating events that occur during or after the tumor development, such as proliferation, angiogenesis, invasion, or cellular death associated or not associated with apoptosis. In the same way, some of these phenylpropanoids also exert stimulatory action on enzymes responsible for metabolizing mutagenic agents or abolish routes of oxidative stress, conditions directly involved in cell transformation.

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  1. Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Miriam Teresa Paz Lopes, Dalton Dittz Júnior & Fernanda de Oliveira Lemos

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  1. Miriam Teresa Paz Lopes
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Correspondence to Miriam Teresa Paz Lopes .

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  1. Federal University of Paraiba, João Pessoa, Paraíba, Brazil

    Damião Pergentino de Sousa

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Paz Lopes, M., Dittz Júnior, D., Lemos, F. (2015). Antitumor Phenylpropanoids. In: de Sousa, D. (eds) Bioactive Essential Oils and Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-19144-7_10

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