Skip to main content

Diagnosis and Management of the Septic Joint

  • Chapter
Osteomyelitis of the Foot and Ankle

Abstract

Pyarthrosis presenting in the ankle or smaller joints of the foot may arise from hematogenous spread of infection, contiguous bone or wound infection, or direct contamination from trauma. While isolated joint sepsis from a hematogenous source is more classically observed in the ankle, joints of the foot can be contaminated by an adjacent ulcer communicating with the joint. Early diagnosis and immediate treatment is important in minimizing potentially devastating local and systemic sequelae associated with this infectious process. Diagnostic criteria is often not absolute and relies in part on clinical suspicion of the physician. Ankle sepsis typically demands immediate intervention consisting of empiric intravenous antibiotic administration and joint lavage. While lavage can be achieved with serial arthrocentesis, we advocate for arthroscopic irrigation and debridement for ankle joint sepsis. The extent of debridement and number of subsequent procedures typically necessary is often contingent on the intraoperative appearance of joint destruction. Low-grade joint sepsis may require a single arthroscopic lavage procedure with minimal synovectomy while an advanced disease process typically necessitates multiple arthroscopic irrigations with extensive synovectomy. An inadequate response to empiric antibiotics and surgical intervention may signal concomitant pathology such as adjacent joint sepsis or osteomyelitis that is not sufficiently being addressed. Sepsis of smaller joints in the foot typically requires open irrigation and debridement often in conjunction with local amputation procedures for effective resection of the infectious nidus. Early identification and prompt intervention is crucial in effectively managing the patient with joint sepsis of the foot or ankle.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Vispo Seara JL, Barthel T, Schmitz H, Eulert J. Arthroscopic treatment of septic joints: prognostic factors. Arch Orthop Trauma Surg. 2002;122:204–11.

    Article  PubMed  CAS  Google Scholar 

  2. Esterhai Jr JL, Gleb I. Adult septic arthritis. Orthop Clin North Am. 1991;22:503–14.

    PubMed  Google Scholar 

  3. Weston VC, Jones AC, Bradbuy N, Fawthrop F, Doherty M. Clinical features and outcome of septic arthritis in a single UK Health District 1982–1991. Ann Rheum Dis. 1999;58:214–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  4. Holtom PD, Lawrence B, Zalavras CG. Hematogenous septic ankle arthritis. Clin Orthop Relat Res. 2008;466:1388–91.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Mathews CJ, Kingsley G, Field M, et al. Management of septic arthritis: a systematic review. Ann Rheum Dis. 2007;66:440–5.

    PubMed  CAS  PubMed Central  Google Scholar 

  6. Gupta MN, Sturrock RD, Field M. A prospective 2-year study of 75 patients with adult-onset septic arthritis. Br J Rheumatol. 2001;40:24–30.

    Article  CAS  Google Scholar 

  7. Goldenberg DL, Cohen AS. Acute infectious arthritis. A review of patients with nongonococcal joint infections (with emphasis on therapy and prognosis). Am J Med. 1976;60:369–77.

    Article  PubMed  CAS  Google Scholar 

  8. Ispahani P, Weston VC, Turner DP, Donald FE. Septic arthritis due to Streptococcus pneumoniae in Nottingham, United Kingdom, 1985–1998. Clin Infect Dis. 1999;29:1450–4.

    Article  PubMed  CAS  Google Scholar 

  9. Margaretten ME, Kohlwes J, Moore D. Does this adult patient have septic arthritis? J Am Med Assoc. 2007;297(13):1478–88.

    Article  CAS  Google Scholar 

  10. Kaandorp CJ, Dinant HJ, van de Laar MA, Moens HJ, Prins AP, Dijkmans BA. Incidence and sources of native and prosthetic joint infection: a community based prospective survey. Ann Rheum Dis. 1997;56:470–5.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  11. Dubost JJ, Fis I, Denis P, Lopitaux R, Soubrier M, Ristori JM, et al. Polyarticular septic arthritis. Medicine (Baltimore). 1993;72:296–310.

    Article  CAS  Google Scholar 

  12. Sharp JT, Lidsky MD, Duffy J, Duncan MW. Infectious arthritis. Arch Intern Med. 1979;139:1125–30.

    Article  PubMed  CAS  Google Scholar 

  13. Meijers KA, Dijkmans BA, Hermans J, van den Broek PJ, Cats A. Nongonococcal infectious arthritis: a retrospective study. J Infect. 1987;14:13–20.

    Article  PubMed  CAS  Google Scholar 

  14. Coakley G, Mathews CJ, Field M, et al. On behalf of the British Society for Rheumatology Standards, Guidelines, and Audit Working Group. BSR & BHPR, BOA, RCGP, and BSAD guidelines for the management of the hot swollen joint in adults. Rheumatology. 2006;45:1039–41.

    Article  PubMed  CAS  Google Scholar 

  15. Söderquist B, Jones I, Fredlund H, Vikerfors T. Bacterial or crystal-associated arthritis? Discriminating ability of serum inflammatory markers. Scand J Infect Dis. 1998;30:591–6.

    Article  PubMed  Google Scholar 

  16. Jeng GW, Wang CR, Liu ST, et al. Measurement of synovial tumor necrosis factor-alpha in diagnosing emergency patients with bacterial arthritis. Am J Emerg Med. 1997;15:626–9.

    Article  PubMed  CAS  Google Scholar 

  17. Li SF, Cassidy C, Change C, et al. Diagnostic utility of laboratory tests in septic arthritis. Emerg Med J. 2007;24:75–7.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  18. Shmerling RH. Synovial fluid analysis: a critical reappraisal. Rheum Dis Clin North Am. 1994;20:503–12.

    PubMed  CAS  Google Scholar 

  19. Klippel JH, Weyand CM, Crofford LJ, Stone JH. Arthritis Foundation: primer on the rheumatic diseases. 12th ed. Atlanta, GA: Arthritis Foundation; 2001.

    Google Scholar 

  20. Edwards CJ, Cooper C, Fischer D, et al. The importance of the disease process and disease-modifying antirheumatic drug treatment in the development of septic arthritis in patients with rheumatoid arthritis. Arthritis Rheum. 2007;57:1151–7.

    Article  PubMed  Google Scholar 

  21. Mathews C, Coakley G. Septic arthritis: current diagnostic and therapeutic algorithm. Curr Opin Rheumatol. 2008;20(4):457–62.

    Article  PubMed  CAS  Google Scholar 

  22. Shetty AK, Gedalia A. Management of septic arthritis. Indian J Pediatr. 2004;71:819–24.

    Article  PubMed  Google Scholar 

  23. Ferroni A. Epidemiologie et diagnostique bacteriologique des infections osteoarticulairesaigues de l’enfant. Arch Pediatr. 2007;14 suppl 2:S91–6.

    Article  PubMed  Google Scholar 

  24. Lane JE, Moore C, Beckish ML, Stephens JL. Isolated septic arthritis caused by penicillin-resistant Streptococcus pneumonia. South Med J. 2001;94:429–31.

    Article  PubMed  CAS  Google Scholar 

  25. Dubost JJ, Soubrier M, De Champs C, Ristori JM, Bussiere JL, Sauvezie B. No changes in the distribution of organisms responsible for septic arthritis over a 20 year period. Ann Rheum Dis. 2002;61:267–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  26. Eder L, Zisman D, Rosenbaum M, Rosner I. Clinical features and aetiology of septic arthritis in northern Israel. Rheumatology. 2005;44:1559–63.

    Article  PubMed  CAS  Google Scholar 

  27. Gupta MN, Sturrock RD, Field M. Prospective comparative study of patients with culture proven and high suspicion of adult onset septic arthritis. Ann Rheum Dis. 2003;62:327–31.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  28. Stutz G, Kuster MS, Kleinstruck F, Gaechter A. Arthroscopic management of septic arthritis: stages of infection and results. Knee Surg Sports Traumatol Arthrosc. 2000;8:270–4.

    Article  PubMed  CAS  Google Scholar 

  29. Der GA. Gelenkinfekt. Inform Arzt. 1986;6:35–43.

    Google Scholar 

  30. Bynum DK, Nunley JA, Goldner JL, Martinez S. Pyogenic arthritis:emphasis on the need for surgical drainage of the infected joint. South Med J. 1982;75:1232–5.

    Article  PubMed  Google Scholar 

  31. Thiery JA. Arthroscopic drainage in septic arthritides of the knee: a multicenter study. Arthroscopy. 1989;5:65–9.

    Article  PubMed  CAS  Google Scholar 

  32. Jerosch J, Hoffstetter I, Schroder M, Castro WHM. Septic arthritis: arthroscopic management with local antibiotic treatment. Acta Orthop Belg. 1995;61:126–34.

    PubMed  CAS  Google Scholar 

  33. Shadrick D, Mendicinio RW, Catanzariti AR. Ankle joint sepsis with subsequent osteomyelitis in an adult patient. J Foot Ankle Surg. 2011;50:354–60.

    Article  PubMed  Google Scholar 

  34. Mankovecky MR, Roukis TS. Arthroscopic synovectomy, irrigation, and debridement for treatment of septic ankle arthrosis: A systematic review and case series. J Foot Ankle Surg. 2014;53(5):615–9.

    Article  PubMed  Google Scholar 

  35. Ferkel RD. Arthroscopy of the foot and ankle. New York: Lippincott Williams & Wilkins/Raven Press; 1996.

    Google Scholar 

  36. Boffeli TB, Hyllengren SB. The forgotten artery in ankle arthroscopy: is the perforating peroneal artery at risk with Standard Anterolateral Portal Placement? J Foot Ankle Surg 2014.

    Google Scholar 

  37. Boffeli TB, Thompson JT. Arthroscopic management of the septic ankle joint: case report of a stage-guided treatment. J Foot Ankle Surg. 2013;52(1):113–7.

    Article  PubMed  Google Scholar 

  38. Wynes J, Harris IV W, Hadfield RA, et al. Subtalar joint septic arthritis in a patient with hypogammaglobulinemia. J Foot Ankle Surg. 2013;52:242–8.

    Article  PubMed  Google Scholar 

  39. Saltzman CL. Salvage of diffuse ankle osteomyelitis by single-stage resection and circumferential frame compression arthrodesis. Iowa Orthop J. 2005;25:47–52.

    PubMed  PubMed Central  Google Scholar 

  40. Baumhauer JF, Lu AP, DiGiovanni BF. Arthrodesis of the infected ankle and subtalar joint. Foot Ankle Clin North Am. 2002;7:175–90.

    Article  Google Scholar 

  41. Klouche S, El-Masri F, Graff W, Mamoudy P. Arthrodesis with internal fixation of the infected ankle. J Foot Ankle Surg. 2011;50:25–30.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jonathan C. Thompson DPM, MHA, AACFAS .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Boffeli, T.J., Thompson, J.C. (2015). Diagnosis and Management of the Septic Joint. In: Boffeli, T. (eds) Osteomyelitis of the Foot and Ankle. Springer, Cham. https://doi.org/10.1007/978-3-319-18926-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-18926-0_9

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18925-3

  • Online ISBN: 978-3-319-18926-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics