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Corticosteroid Receptors

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Nuclear Receptors: From Structure to the Clinic

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Abstract

The mineralocorticoid receptor (MR) mediates the effects of aldosterone in epithelial tissues. The MR is also expressed in many other tissues where its role may be that of a cortisol/corticosterone receptor. The MR is a member of the nuclear receptor superfamily and as such contains three principal structural domains, the N-terminal domain, the DNA-binding domain and the ligand-binding domain. The latter two exhibit both structural and functional features which overlap with those of other steroid receptors whereas the N-terminal domain exhibits a number of unique structural features. The various interactions of the MR both between domains and with other molecules serve to determine both ligand specificity, sensitivity and tissue-specific responses. An increasing focus on the importance of MR blockade in a range of clinical conditions makes an understanding of structure-function relationships an imperative if novel therapeutic strategies are to be developed.

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Acknowledgements

The authors wish to thank Claudette Thiedeman for preparation of the manuscript. This work was supported by the National Health & Medical Research Council of Australia through a Senior Principal Research Fellowship to PJF (#1002559). MIMR-PHI Institute is supported by the Victorian Government’s Operational Infrastructure Program.

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  1. MIMR-PHI Institute (Prince Henry’s Institute), 27-31 Wright Street, 3168, Clayton, VIC, Australia

    Peter J. Fuller, Jun Yang & Morag J. Young

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Correspondence to Peter J. Fuller .

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  1. School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

    Iain J. McEwan

  2. Department of Basic Sciences, The Commonwealth Medical College, Scranton, Pennsylvania, USA

    Raj Kumar

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Fuller, P., Yang, J., Young, M. (2015). Corticosteroid Receptors. In: McEwan, I., Kumar, R. (eds) Nuclear Receptors: From Structure to the Clinic. Springer, Cham. https://doi.org/10.1007/978-3-319-18729-7_2

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