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Pharmacology of TRP Channels

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TRP Channels in Sensory Transduction

Abstract

TRP channels are a family of ion channels involved in a plethora of physiological sensory processes. Since their discovery they have attracted the attention of academic and non-academic laboratories with the aim of developing modulators that could be used as pharmacological tools for unveiling their physiological and pathological activities, and as therapeutic compounds for intervening in TRP dysfunction. Intriguingly, TRP pharmacology shows dispersed progress, with vast pharmacology developed for some members of the so-called thermoTRP channel subfamily (TRPV1, TRPV3, TRPM8 and TRPA1), and very little, for all other TRP channels. Pharmacologically, the most investigated TRP channel is undoubtedly TRPV1 for which a large number of agonists and antagonists with in vitro and in vivo activities have been characterized. Recent interest has grown for TRPV3, TRPM8 and TRPA1 because of their implication in several human pathologies and disorders. Similarly, the TRPM3 channel is emerging as important targets for pain transduction. With the development of novel screening methods, the focus is slowly changing to other TRP members for whom we do not have appropriate agonists or antagonists. These include the TRPC family, which has limited our understanding of their role in pathological processes and whether pharmacological intervention in these channels will have a therapeutic benefit. A bright future is anticipated for TRP pharmacology, with the discovery of selective and potent modulators for this important family of sensory channels.

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Acknowledgement

We are indebted to the members of our laboratories, to our collaborators, and the funding from the Ministry of Economy and Competitiveness (BFU2012-39092-C02-01/02, and CSD2008-00005), and the Generalitat Valenciana (PROMETEO/2010/046 and ISIC/2012/009).

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Authors and Affiliations

  1. Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Edificio Torregaitán, 03202, Elche, Alicante, Spain

    Asia Fernández-Carvajal, Gregorio Fernández-Ballester & Antonio Ferrer-Montiel

  2. Instituto de Química Médica, CSIC, Madrid, Spain

    Rosario González-Muñiz

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  1. Asia Fernández-Carvajal
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  2. Gregorio Fernández-Ballester
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  3. Rosario González-Muñiz
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  4. Antonio Ferrer-Montiel
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Correspondence to Antonio Ferrer-Montiel .

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Editors and Affiliations

  1. Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile

    Rodolfo Madrid

  2. Faculty of Science, University of Chile, Santiago, Chile

    Juan Bacigalupo

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Fernández-Carvajal, A., Fernández-Ballester, G., González-Muñiz, R., Ferrer-Montiel, A. (2015). Pharmacology of TRP Channels. In: Madrid, R., Bacigalupo, J. (eds) TRP Channels in Sensory Transduction. Springer, Cham. https://doi.org/10.1007/978-3-319-18705-1_2

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