Abstract
Ovulation is simply the focal destruction of the follicular wall that enables extrusion of the oocyte and follicular contents through the breach. A space of some 36–40 h passes from the initial gonadotropin surge to the follicular rupture itself, during which irreversible actions reprogram the entire structure and function of the follicle, reawaken oocyte meiosis, alter the follicular wall, and commence the process of luteinization.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Franchimont F, Hazee-Hagelstein MT, Charlet-Renard B et al (1994) Some basic mechanisms of ovulation. In: Emperaire JC (ed) The triggering of ovulation in stimulated cycles: HCG or LH? The Parthenon Publishing Group, London, pp 13–20
Hoff JD, Quidgley ME, Yen SSC (1983) Hormonal dynamics at mid-cycle: a reevaluation. J Clin Endocrinol Metab 57:792–796
Testard J, Frydman R, Feinstein MC et al (1998) Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge initiating rise. Fertil Steril 36:50–54
Cohlen BJ, TeVelde ER, Scheffer G et al (1993) The pattern of the luteinizing hormone surge in spontaneous cycles is correlated to the probability of conception. Fertil Steril 60:413–417
Bianchi V, Dal Prato L, Maccolini A et al (2009) Inadvertent recombinant follicle stimulating hormone bolus instead of human chorionic gonadotropin leads to the retrieval of competent oocytes in IVF program. Fertil Steril 92:1747.e1–1747.e3
Lamb JD, Shen S, McCulloch C et al (2011) Follicle stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization cycles: a randomized, double-blind, placebo-controlled trial. Fertil Steril 95:1655–1660
Shalom-Paz E, Marzal A, Wiser A et al (2014) Does optimal follicular size vary between clomiphene citrate and gonadotropin treatments? Gynecol Endocrinol 30:107–110
Da Silva A, Arbo E, Franchin R (2012) Early versus late HMG administration in mild-stimulated IUI cycles: a randomized clinical trial. Eur J Obstet Gynecol Reprod Biol 164:156–160
Loumaye E, Engrand P, Howles CM, O’Dean L (1997) An assessment of the role of serum luteinizing hormone and estradiol response to follicle stimulating hormone on the in vitro fertilization treatment outcome. Fertil Steril 67:889–899
Crosignani PG, Donini P (1994) The triggering of ovulation with partially desialylated HCG in HMG-stimulated cycles. In: Emperaire JC (ed) The triggering of ovulation in stimulated cycles: hCG or LH? The Parthenon Publishing Group, New York, pp 99–102
Le Cotonnec JY, Porchet HC, Beltrami V, Munafo A (1998) Clinical pharmacology of human luteinizing hormone. Part I. Pharmacokinetics after intravenous administration to healthy female volunteers and comparison with urinary human luteinizing hormone. Fertil Steril 69:189–194
Damewood MD, Shen W, Zacur HA et al (1989) Disappearance of exogenously administered human chorionic gonadotropin. Fertil Steril 52:398–402
Rizkallah T, Gurpide E, Van De Wiele RL (1969) Metabolism of HCG in man. J Clin Endocrinol Metab 29:92–100
Morse JH, Lustbader JW, Harrington JW, Canfield RE (1988) Heterogeneity of proteins in commercial preparations of human chorionic gonadotropin (hCG) demonstrated by western blotting. Am J Reprod Immunol 17:134–140
Bomsel-Helmreich O, Vun Nuyen L, Durand-Gasselin I (1989) Effects of varying doses of HCG on the evolution of preovulatory rabbit follicles and oocytes. Hum Reprod 4:636–642
Brown JB (1978) Pituitary control of ovarian function – concepts derived from gonadotrophin therapy. Aust N Z J Obstet Gynaecol 18:47–54
Abdallah H, Ah-Moye M (1987) The effect of the dose of HCG and the type of gonadotropin stimulation on oocyte recovery rate. Fertil Steril 48:958–963
Salha O, Dada T, Sharma V (2001) Influence of body mass index and self-administration of HCG on the outcome of IVF cycles: a prospective cohort study. Hum Fertil 4:37–42
Zelinski-Wooten MB, Hutchison JS, Trinchard-Lugan I et al (1997) Initiation of periovulatory events in gonadotropin-stimulated macaques with various doses of recombinant human chorionic gonadotropin. Hum Reprod 12:1877–1885
Emperaire JC, Parneix I, Broussin B, Ruffie A (1998) Triggering ovulation with different doses of human chorionic gonadotropin (hCG) in stimulated cycles. In: 16th World Congress on Fertility and Sterility, San Francisco, Abstr O-147, p 55
Fischer RA, Nakajima ST, Gibson M, Brumsted JR (1993) Ovulation after intravenous and intramuscular human chorionic gonadotropin. Fertil Steril 60:413–417
Chan CC, Ng EH, Tang OS et al (2005) A prospective, randomized double-blind study to compare two doses of recombinant human chorionic gonadotropin in inducing final oocyte maturity and the hormonal profile during the luteal phase. J Clin Endocrinol Metab 90:3933–3938
Fuh KW, Wang X, Tai A et al (1997) Intra-uterine insemination: effect of temporal relationship between the luteinizing hormone surge, human chorionic gonadotropin administration, and insemination on pregnancy rates. Hum Reprod 12:2162–2166
Blockeel C, Knez J, Polyzos NP et al (2014) Should an intra-uterine insemination with donor semen be performed 1 or 2 days after the spontaneous LH rise? A prospective RCT. Hum Reprod 29:697–703
Emperaire JC (1994) Le declenchement therapeutique de l’ovulation: vers le remplacement de l’HCG par la LH. Contracept Fertil Sexual 22:459–467
Parneix I, Emperaire JC, Ruffie A (2001) Comparaison de differents protocoles de declenchement ovulatoire par les agonistes de la GnRH et la gonadotrophine chorionique. Gynecol Obstet Fertil 29:100–115
Iliodromiti S, Lan VT, Tuong HM et al (2013) Impact of GnRH agonist triggering and extensive luteal support on live-birth rates and ovarian hyperstimulation syndrome: a retrospective cohort study. J Ovarian Res 6:93
Emperaire JC, Parneix I, Ruffie A (2004) Luteal phase defects following agonist-triggered ovulation: a patient-dependent response. Reprod Biomed Online 9:22–27
The European Recombinant LH Study Group (2001) The recombinant luteinizing hormone is as effective as, but safer than, urinary human chorionic gonadotropin in inducing final follicular maturation and ovulation in in vitro fertilization procedures: results of a multicenter double-blind study. J Clin Endocrinol Metab 86:2607–2618
Chandrasekher YA, Hutchison JS, Zelinski-Wooten MB et al (1994) Initiation of periovulatory events in primate follicles using recombinant and native human luteinizing hormone to mimic the mid-cycle gonadotropin surge. J Clin Endocrinol Metab 79:298–306
Jewelewicz R, James SL, Finster M et al (1972) Quintuplet gestation after ovulation induction with menopausal gonadotropins and pituitary luteinizing hormone. Obstet Gynecol 40:1–5
Mehrotra S, Singh U, Gupta HP et al (2014) A prospective double blind study comparing the effects of oxytocin and human chorionic gonadotrophin as trigger for ovulation. J Obstet Gynecol 34:13–16
Emperaire JC, Edwards RG (2004) Time to revolutionize the triggering of ovulation. Reprod Biomed Online 9:480–483
Emperaire JC (2005) Pourquoi continuer à tolérer l’hyperstimulation ovarienne? Gynecol Obstet Fertil 33:281–282
Caraty A, Evans NP, Fabre-Nys CJ, Karsch EJ (1995) The periovulatory gonadotropin-releasing hormone surge: a neuroendocrine signal for ovulation. J Reprod Fertil Suppl 49:245–255
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Emperaire, JC. (2015). Triggering Ovulation. In: Ovulation Stimulation with Gonadotropins. Springer, Cham. https://doi.org/10.1007/978-3-319-18654-2_6
Download citation
DOI: https://doi.org/10.1007/978-3-319-18654-2_6
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-18653-5
Online ISBN: 978-3-319-18654-2
eBook Packages: MedicineMedicine (R0)