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The Pathophysiology of Flail Chest Injury

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Abstract

Thoracic trauma is a commonly encountered entity in a trauma center and may present as a simple superficial abrasion to more severe and often life-threatening conditions like tension pneumothorax, cardiac tamponade, flail chest, and pulmonary contusion. The structures involved can vary from the overlying skin to the underlying ribs, muscles, lung, heart, and major blood vessels. Management of these disorders in general, and flail chest with pulmonary contusion in particular, is extremely challenging from a clinical perspective and requires in-depth knowledge of underlying pathophysiology. This chapter will focus on the intrathoracic pathophysiology associated with a flail chest injury.

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References

  1. Vana PG, Neubauer DC, Luchette FA. Contemporary management of flail chest. Am Surg. 2014;80:527–35.

    PubMed  Google Scholar 

  2. Veysi VT, Nikolaou VS, Paliobeis C, Efstathopoulos N, Giannoudis PV. Prevalence of chest trauma, associated injuries and mortality: a level I trauma centre experience. Int Orthop. 2009;33:1425–33.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Ziegler DW, Agarwal NN. The morbidity and mortality of rib fractures. J Trauma. 1994;37:975–9.

    Article  CAS  PubMed  Google Scholar 

  4. Gaillard M, Hervé C, Mandin L, Raynaud P. Mortality prognostic factors in chest injury. J Trauma. 1990;30:93–6.

    Article  CAS  PubMed  Google Scholar 

  5. Newman RJ, Jones IS. A prospective study of 413 consecutive car occupants with chest injuries. J Trauma. 1984;24:129–35.

    Article  CAS  PubMed  Google Scholar 

  6. Shorr RM, Crittenden M, Indeck M, Hartunian SL, Rodriguez A. Blunt thoracic trauma. Analysis of 515 patients. Ann Surg. 1987;206:200–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Bergeron E, et al. Elderly trauma patients with rib fractures are at greater risk of death and pneumonia. J Trauma. 2003;54:478–85.

    Article  PubMed  Google Scholar 

  8. Bastos R, Calhoon JH, Baisden CE. Flail chest and pulmonary contusion. Semin Thorac Cardiovasc Surg. 2008;20:39–45.

    Article  PubMed  Google Scholar 

  9. Bulger EM, Arneson MA, Mock CN, Jurkovich GJ. Rib fractures in the elderly. J Trauma. 2000;48:1040–6. discussion 1046–7.

    Article  CAS  PubMed  Google Scholar 

  10. Wanek S, Mayberry JC. Blunt thoracic trauma: flail chest, pulmonary contusion, and blast injury. Crit Care Clin. 2004;20:71–81.

    Article  PubMed  Google Scholar 

  11. Kleinman PK, Schlesinger AE. Mechanical factors associated with posterior rib fractures: laboratory and case studies. Pediatr Radiol. 1997;27:87–91.

    Article  CAS  PubMed  Google Scholar 

  12. Shen W, Niu Y, Stuhmiller JH. Biomechanically based criteria for rib fractures induced by high-speed impact. J Trauma. 2005;58:538–45.

    Article  PubMed  Google Scholar 

  13. Borrelly J, Aazami MH. New insights into the pathophysiology of flail segment: the implications of anterior serratus muscle in parietal failure. Eur J Cardiothorac Surg. 2005;28:742–9.

    Article  PubMed  Google Scholar 

  14. Ahmed Z, Mohyuddin Z. Management of flail chest injury: internal fixation versus endotracheal intubation and ventilation. J Thorac Cardiovasc Surg. 1995;110:1676–80.

    Article  CAS  PubMed  Google Scholar 

  15. Cappello M, Yuehua C, De Troyer A. Respiratory muscle response to flail chest. Am J Respir Crit Care Med. 1996;153:1897–901.

    Article  CAS  PubMed  Google Scholar 

  16. Cappello M, Legrand A, De Troyer A. Determinants of rib motion in flail chest. Am J Respir Crit Care Med. 1999;159:886–91.

    Article  CAS  PubMed  Google Scholar 

  17. Cappello M, De Troyer A. Actions of the inspiratory intercostal muscles in flail chest. Am J Respir Crit Care Med. 1997;155:1085–9.

    Article  CAS  PubMed  Google Scholar 

  18. Rib Fracture Imaging. Available from: http://emedicine.medscape.com/article/395172-overview.

  19. Greene R. Lung alterations in thoracic trauma. J Thorac Imaging. 1987;2:1–11.

    Article  CAS  PubMed  Google Scholar 

  20. Collins J. Chest wall trauma. J Thorac Imaging. 2000;15:112–9.

    Article  CAS  PubMed  Google Scholar 

  21. Bailey P. Surfer’s rib: isolated first rib fracture secondary to indirect trauma. Ann Emerg Med. 1985;14:346–9.

    Article  CAS  PubMed  Google Scholar 

  22. Sadaba JR, Oswal D, Munsch CM. Management of isolated sternal fractures: determining the risk of blunt cardiac injury. Ann R Coll Surg Engl. 2000;82:162–6.

    PubMed Central  CAS  PubMed  Google Scholar 

  23. Berg EE. The sternal-rib complex. A possible fourth column in thoracic spine fractures. Spine (Phila Pa 1976). 1993;18:1916–9.

    Article  CAS  Google Scholar 

  24. Denis F. The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine (Phila Pa 1976). 1983;8:817–31.

    Article  CAS  Google Scholar 

  25. Pal JM, Mulder DS, Brown RA, Fleiszer DM. Assessing multiple trauma: is the cervical spine enough? J Trauma. 1988;28:1282–4.

    Article  CAS  PubMed  Google Scholar 

  26. Liman ST, Kuzucu A, Tastepe AI, Ulasan GN, Topcu S. Chest injury due to blunt trauma. Eur J Cardiothorac Surg. 2003;23:374–8.

    Article  PubMed  Google Scholar 

  27. Simon B, et al. Management of pulmonary contusion and flail chest: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg. 2012;73:S351–61.

    Article  PubMed  Google Scholar 

  28. Fulton RL, Peter ET. The progressive nature of pulmonary contusion. Surgery. 1970;67:499–506.

    CAS  PubMed  Google Scholar 

  29. Cohn SM. Pulmonary contusion: review of the clinical entity. J Trauma. 1997;42:973–9.

    Article  CAS  PubMed  Google Scholar 

  30. Wagner RB, Crawford WO, Schimpf PP. Classification of parenchymal injuries of the lung. Radiology. 1988;167:77–82.

    Article  CAS  PubMed  Google Scholar 

  31. Wagner RB, Jamieson PM. Pulmonary contusion. Evaluation and classification by computed tomography. Surg Clin North Am. 1989;69:31–40.

    CAS  PubMed  Google Scholar 

  32. Gebhard F, Kelbel MW, Strecker W, Kinzl L, Brückner UB. Chest trauma and its impact on the release of vasoactive mediators. Shock. 1997;7:313–7.

    Article  CAS  PubMed  Google Scholar 

  33. Keel M, et al. Different pattern of local and systemic release of proinflammatory and anti-inflammatory mediators in severely injured patients with chest trauma. J Trauma. 1996;40:907–12. discussion 912–4.

    Article  CAS  PubMed  Google Scholar 

  34. Miller PR, et al. ARDS after pulmonary contusion: accurate measurement of contusion volume identifies high-risk patients. J Trauma. 2001;51:223–8. discussion 229–30.

    Article  CAS  PubMed  Google Scholar 

  35. Azoulay E, et al. Exacerbation by granulocyte colony-stimulating factor of prior acute lung injury: implication of neutrophils. Crit Care Med. 2002;30:2115–22.

    Article  CAS  PubMed  Google Scholar 

  36. Abraham E, Carmody A, Shenkar R, Arcaroli J. Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1137–45.

    CAS  PubMed  Google Scholar 

  37. Li M, et al. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol. 2001;166:7128–35.

    Article  CAS  PubMed  Google Scholar 

  38. Raghavendran K, et al. The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses. Shock. 2005;24:132–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  39. Seitz DH, et al. Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils. Shock. 2008;30:537–44.

    Article  PubMed  Google Scholar 

  40. Perl M, et al. Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge. Crit Care Med. 2005;33:1351–8.

    Article  PubMed  Google Scholar 

  41. Liener UC, et al. Induction of apoptosis following blunt chest trauma. Shock. 2003;20:511–6.

    Article  PubMed  Google Scholar 

  42. Matute-Bello G, Martin TR. Science review: apoptosis in acute lung injury. Crit Care. 2003;7:355–8.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Hoth JJ, et al. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007;28:447–52.

    Article  CAS  PubMed  Google Scholar 

  44. Hoth JJ, et al. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009;31:376–81.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  45. Raghavendran K, et al. Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model. Shock. 2008;30:508–17.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  46. Oppenheimer L, Craven KD, Forkert L, Wood LD. Pathophysiology of pulmonary contusion in dogs. J Appl Physiol. 1979;47:718–28.

    CAS  PubMed  Google Scholar 

  47. Hellinger A, et al. Does lung contusion affect both the traumatized and the noninjured lung parenchyma? A morphological and morphometric study in the pig. J Trauma. 1995;39:712–9.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Shalini Nair M.D. .

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Tiwari, A., Nair, S., Baker, A. (2015). The Pathophysiology of Flail Chest Injury. In: McKee, M., Schemitsch, E. (eds) Injuries to the Chest Wall. Springer, Cham. https://doi.org/10.1007/978-3-319-18624-5_3

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  • DOI: https://doi.org/10.1007/978-3-319-18624-5_3

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18623-8

  • Online ISBN: 978-3-319-18624-5

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