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Fat-Soluble Vitamins

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Nutrition Physiology and Metabolism in Spaceflight and Analog Studies

Part of the book series: SpringerBriefs in Space Life Sciences ((BRIEFSSLS))

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Abstract

For a compound to be considered a vitamin, it has to be an essential component of the diet, a dietary essential. The elimination of a vitamin from the diet must result in a more or less clearly defined deficiency disease (Bender 2009). Vitamins are classified as either fat soluble or water soluble. In light of the astronauts’ inadequate dietary intake, the use of vitamin and mineral supplements is often debated (Smith et al. 2001). However, the deficient energy intake of the astronauts is clearly the issue having highest priority. If dietary intake increases, the intake of all nutrients, including the vitamins and minerals, will increase. Fat-soluble vitamins (A, D, E, and K) are soluble in lipids and are usually absorbed in fat globules.

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References

  • Adams JS, Hewison M (2008) Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 4(2):80–90, available from: PM:18212810

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Arbour NC, Darwish HM, DeLuca HF (1995) Transcriptional control of the osteocalcin gene by 1,25-dihydroxyvitamin D-2 and its 24-epimer in rat osteosarcoma cells. Biochim Biophys Acta 1263(2):147–153, available from: PM:7640305

    Article  PubMed  Google Scholar 

  • Arnson Y, Amital H, Shoenfeld Y (2007) Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis 66(9):1137–1142, available from: PM:17557889

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Autier P, Gandini S (2007) Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 167(16):1730–1737, available from: PM:17846391

    Article  CAS  PubMed  Google Scholar 

  • Bagger YZ, Tanko LB, Alexandersen P, Qin G, Christiansen C (2006) Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J Intern Med 259(6):598–605, available from: PM:16704561

    Article  CAS  PubMed  Google Scholar 

  • Barnard K, Colon-Emeric C (2010) Extraskeletal effects of vitamin D in older adults: cardiovascular disease, mortality, mood, and cognition. Am J Geriatr Pharmacother 8(1):4–33, available from: PM:20226390

    Article  CAS  PubMed  Google Scholar 

  • Bender DA (2009) Nutritional biochemistry of the vitamins, 2nd edn. Cambridge University Press, Cambridge

    Google Scholar 

  • Bergwitz C, Juppner H (2010) Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med 61:91–104, available from: PM:20059333

    Article  CAS  PubMed  Google Scholar 

  • Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PW, Ordovas J, Schaefer EJ, Dawson-Hughes B, Kiel DP (2000) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 71(5):1201–1208, available from: PM:10799384

    CAS  PubMed  Google Scholar 

  • Booth SL, Broe KE, Peterson JW, Cheng DM, Dawson-Hughes B, Gundberg CM, Cupples LA, Wilson PW, Kiel DP (2004) Associations between vitamin K biochemical measures and bone mineral density in men and women. J Clin Endocrinol Metab 89(10):4904–4909, available from: PM:15472183

    Article  CAS  PubMed  Google Scholar 

  • Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29(6):726–776, available from: PM:18694980

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Caillot-Augusseau A, Vico L, Heer M, Voroviev D, Souberbielle JC, Zitterman A, Alexandre C, Lafage-Proust MH (2000) Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: observations in two cosmonauts. Clin Chem 46(8 Pt 1):1136–1143

    CAS  PubMed  Google Scholar 

  • Card DJ, Gorska R, Cutler J, Harrington DJ (2014) Vitamin K metabolism: current knowledge and future research. Mol Nutr Food Res 58(8):1590–1600, available from: PM:24376012

    Article  CAS  PubMed  Google Scholar 

  • Carvalho JF, Blank M, Kiss E, Tarr T, Amital H, Shoenfeld Y (2007) Anti-vitamin D, vitamin D in SLE: preliminary results. Ann N Y Acad Sci 1109:550–557, available from: PM:17785344

    Article  CAS  PubMed  Google Scholar 

  • Christian P, West KP Jr, Khatry SK, Katz J, LeClerq S, Pradhan EK, Shrestha SR (1998) Vitamin A or beta-carotene supplementation reduces but does not eliminate maternal night blindness in Nepal. J Nutr 128(9):1458–1463, available from: PM:9732305

    CAS  PubMed  Google Scholar 

  • Deluca HF (1974) Vitamin D: the vitamin and the hormone. Fed Proc 33(11):2211–2219, available from: PM:4372106

    CAS  PubMed  Google Scholar 

  • Deluca HF (2008) Evolution of our understanding of vitamin D. Nutr Rev 66(10 Suppl 2):S73–S87, available from: PM:18844850

    Article  PubMed  Google Scholar 

  • Deluca HF, Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15(14):2579–2585, available from: PM:11726533

    Article  CAS  PubMed  Google Scholar 

  • Food and Nutrition Board, I.o.M. (2001) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. National Academy Press, Washington, DC

    Google Scholar 

  • Galitzer H, Ben-Dov I, Lavi-Moshayoff V, Naveh-Many T, Silver J (2008) Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion. Curr Opin Nephrol Hypertens 17(4):363–367, available from: PM:18660671

    Article  CAS  PubMed  Google Scholar 

  • Gmunder FK, Konstantinova I, Cogoli A, Lesnyak A, Bogomolov W, Grachov AW (1994) Cellular immunity in cosmonauts during long duration spaceflight on board the orbital MIR station. Aviat Space Environ Med 65(5):419–423, available from: PM:8024524

    CAS  PubMed  Google Scholar 

  • Hart JP, Shearer MJ, Klenerman L, Catterall A, Reeve J, Sambrook PN, Dodds RA, Bitensky L, Chayen J (1985) Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab 60(6):1268–1269, available from: PM:3998071

    Article  CAS  PubMed  Google Scholar 

  • Heaney RP (2003) Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 78(5):912–919, available from: PM:14594776

    CAS  PubMed  Google Scholar 

  • Heer M (2002) Nutritional interventions related to bone turnover in European space missions and simulation models. Nutrition 18(10):853–856, available from: PM:12361778

    Article  CAS  PubMed  Google Scholar 

  • Holick MF (2006) Resurrection of vitamin D deficiency and rickets. J Clin Invest 116(8):2062–2072, available from: PM:16886050

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281, available from: PM:17634462

    Article  CAS  PubMed  Google Scholar 

  • IOM (Institute of Medicine) (2000) Dietary reference intakes for vitamin E, selenium, and carotenoids. The National Academy Press, Washington, DC

    Google Scholar 

  • IOM (Institute of Medicine) (2002a) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. The National Academy Press, Washington, DC

    Google Scholar 

  • IOM (Institute of Medicine) (2002b) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. The National Academy Press, Washington, DC

    Google Scholar 

  • IOM (Institute of Medicine) (2011) Dietary reference intakes for calcium and vitamin D. The National Academy Press, Washington, DC

    Google Scholar 

  • Jurutka PW, Whitfield GK, Hsieh JC, Thompson PD, Haussler CA, Haussler MR (2001) Molecular nature of the vitamin D receptor and its role in regulation of gene expression. Rev Endocr Metab Disord 2(2):203–216, available from: PM:11705326

    Article  CAS  PubMed  Google Scholar 

  • Knapen MH, Hamulyak K, Vermeer C (1989) The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion. Ann Intern Med 111(12):1001–1005

    Article  CAS  PubMed  Google Scholar 

  • Knapen MH, Jie KS, Hamulyak K, Vermeer C (1993) Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss. Calcif Tissue Int 53(2):81–85

    Article  CAS  PubMed  Google Scholar 

  • Larsen ER, Mosekilde L, Foldspang A (2004) Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res 19(3):370–378, available from: PM:15040824

    Article  CAS  PubMed  Google Scholar 

  • Loehr JA, Lee SM, English KL, Sibonga J, Smith SM, Spiering BA, Hagan RD (2011) Musculoskeletal adaptations to training with the advanced resistive exercise device. Med Sci Sports Exerc 43(1):146–156, available from: PM:20473227

    Article  PubMed  Google Scholar 

  • Masuda S, Jones G (2006) Promise of vitamin D analogues in the treatment of hyperproliferative conditions. Mol Cancer Ther 5(4):797–808, available from: PM:16648549

    Article  CAS  PubMed  Google Scholar 

  • National Aeronautics and Space Administration Johnson Space Center (1996) Nutritional requirements for International Space Station (ISS) missions up to 360 days. NASA, Houston, TX

    Google Scholar 

  • National Research Council (2000) Dietary reference intakes for calcium, phosphoruns, magnesium, vitamin D, and fluorid. The National Academic Press, Washington, DC

    Google Scholar 

  • Orbach H, Zandman-Goddard G, Amital H, Barak V, Szekanecz Z, Szucs G, Danko K, Nagy E, Csepany T, Carvalho JF, Doria A, Shoenfeld Y (2007) Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D, and TPA levels in autoimmune diseases. Ann N Y Acad Sci 1109:385–400, available from: PM:17785327

    Article  CAS  PubMed  Google Scholar 

  • Palacios C (2006) The role of nutrients in bone health, from A to Z. Crit Rev Food Sci Nutr 46(8):621–628, available from: PM:17092827

    Article  CAS  PubMed  Google Scholar 

  • Peterlik M, Cross HS (2009) Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Eur J Clin Nutr 63(12):1377–1386, available from: PM:19724293

    Article  CAS  PubMed  Google Scholar 

  • Pilz S, Tomaschitz A, Marz W, Drechsler C, Ritz E, Zittermann A, Cavalier E, Pieber TR, Lappe JM, Grant WB, Holick MF, Dekker JM (2011) Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf) 75(5):575–584, available from: PM:21682758

    Article  CAS  Google Scholar 

  • Raica N Jr, Scott J, Lowry L, Sauberlich HE (1972) Vitamin A concentration in human tissues collected from five areas in the United States. Am J Clin Nutr 25(3):291–296, available from: PM:5011912

    PubMed  Google Scholar 

  • Rettberg P, Horneck G, Zittermann A, Heer M (1998) Biological dosimetry to determine the UV radiation climate inside the MIR station and its role in vitamin D biosynthesis. Adv Space Res 22(12):1643–1652, available from: PM:11542408

    Article  CAS  PubMed  Google Scholar 

  • Ross AC (1992) Vitamin A status: relationship to immunity and the antibody response. Proc Soc Exp Biol Med 200(3):303–320, available from: PM:1615007

    Article  CAS  PubMed  Google Scholar 

  • Schneider SM, Amonette WE, Blazine K, Bentley J, Lee SM, Loehr JA, Moore AD Jr, Rapley M, Mulder ER, Smith SM (2003) Training with the International Space Station interim resistive exercise device. Med Sci Sports Exerc 35(11):1935–1945, available from: PM:14600562

    Article  PubMed  Google Scholar 

  • Shearer MJ (1995) Vitamin K. Lancet 345(8944):229–234, available from: PM:7823718

    Article  CAS  PubMed  Google Scholar 

  • Smith SM, Wastney ME, Morukov BV, Larina IM, Nyquist LE, Abrams SA, Taran EN, Shih CY, Nillen JL, Davis-Street JE, Rice BL, Lane HW (1999) Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes. Am J Physiol 277(1 Pt 2):R1–R10

    Article  CAS  PubMed  Google Scholar 

  • Smith SM, Davis-Street JE, Rice BL, Nillen JL, Gillman PL, Block G (2001) Nutritional status assessment in semiclosed environments: ground-based and space flight studies in humans. J Nutr 131(7):2053–2061, available from: PM:11435529

    CAS  PubMed  Google Scholar 

  • Smith SM, Zwart SR, Block G, Rice BL, Davis-Street JE (2005b) The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J Nutr 135(3):437–443, available from: PM:15735075

    CAS  PubMed  Google Scholar 

  • Smith SM, Zwart SR, Kloeris V, Heer M (2009) Nutritional biochemistry of space flight, 2009th edn. Nova Science Publishers, New York

    Google Scholar 

  • Smith SM, Heer MA, Shackelford LC, Sibonga JD, Ploutz-Snyder L, Zwart SR (2012a) Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: evidence from biochemistry and densitometry. J Bone Miner Res 27(9):1896–1906, available from: PM:22549960

    Article  CAS  PubMed  Google Scholar 

  • Sokoll LJ, Booth SL, O’Brien ME, Davidson KW, Tsaioun KI, Sadowski JA (1997) Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. Am J Clin Nutr 65(3):779–784, available from: PM:9062529

    CAS  PubMed  Google Scholar 

  • National Aeronautics and Space Administration Johnson Space Center (2005) Nutrition requirements, standards, and operating bands for exploration missions. JSC Document #63555 ed. NASA, Houston, TX

    Google Scholar 

  • Stephensen CB (2001) Vitamin A, infection, and immune function. Annu Rev Nutr 21:167–192, available from: PM:11375434

    Article  CAS  PubMed  Google Scholar 

  • Sugiyama T, Kawai S (2001) The use of vitamin K may be a good choice for microgravity-induced bone disorder. J Bone Miner Res 16(4):794–795, available from: PM:11316009

    Article  CAS  PubMed  Google Scholar 

  • Szulc P, Chapuy MC, Meunier PJ, Delmas PD (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18(5):487–488, available from: PM:8739908

    Article  CAS  PubMed  Google Scholar 

  • Traber MG (1999) Utilization of vitamin E. Biofactors 10(2-3):115–120, available from: PM:10609871

    Article  CAS  PubMed  Google Scholar 

  • Trivedi DP, Doll R, Khaw KT (2003) Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326(7387):469, available from: PM:12609940

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ushiroyama T, Ikeda A, Ueki M (2002) Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas 41(3):211–221, available from: PM:11886767

    Article  CAS  PubMed  Google Scholar 

  • Vergnaud P, Garnero P, Meunier PJ, Breart G, Kamihagi K, Delmas PD (1997) Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study [see comments]. J Clin Endocrinol Metab 82(3):719–724

    CAS  PubMed  Google Scholar 

  • Vermeer C, Hamulyak K (1991) Pathophysiology of vitamin K-deficiency and oral anticoagulants. Thromb Haemost 66(1):153–159, available from: PM:1926045

    CAS  PubMed  Google Scholar 

  • Vermeer C, Jie KS, Knapen MH (1995) Role of vitamin K in bone metabolism. Annu Rev Nutr 15:1–22

    Article  CAS  PubMed  Google Scholar 

  • Virtamo J, Taylor PR, Kontto J, Mannisto S, Utriainen M, Weinstein SJ, Huttunen J, Albanes D (2014) Effects of alpha-tocopherol and beta-carotene supplementation on cancer incidence and mortality: 18-year postintervention follow-up of the Alpha-tocopherol, Beta-carotene Cancer Prevention Study. Int J Cancer 135(1):178–185, available from: PM:24338499

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zittermann A (2010) The estimated benefits of vitamin D for Germany. Mol Nutr Food Res 54(8):1164–1171, available from: PM:20373291

    CAS  PubMed  Google Scholar 

  • Zittermann A, Gummert JF (2010) Sun, vitamin D, and cardiovascular disease. J Photochem Photobiol B 101(2):124–129, available from: PM:20138781

    Article  CAS  PubMed  Google Scholar 

  • Zwart SR, Oliver SA, Fesperman JV, Kala G, Krauhs J, Ericson K, Smith SM (2009b) Nutritional status assessment before, during, and after long-duration head-down bed rest. Aviat Space Environ Med 80(5 Suppl):A15–A22, available from: PM:19476165

    Article  CAS  PubMed  Google Scholar 

  • Zwart SR, Booth SL, Peterson JW, Wang Z, Smith SM (2011a) Vitamin K status in spaceflight and ground-based models of spaceflight. J Bone Miner Res 26(5):948–954, available from: PM:21541997

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zwart SR, Mehta SK, Ploutz-Snyder R, Bourbeau Y, Locke JP, Pierson DL, Smith SM (2011b) Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus Reactivation. J Nutr 141(4):692–697, available from: PM:21539011

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Nutrition Physiology, University of Bonn, Bonn, Germany

    Martina Heer & Natalie Baecker

  2. Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, USA

    Jens Titze

  3. Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, Texas, USA

    Scott M. Smith

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  1. Martina Heer
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  2. Jens Titze
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  3. Scott M. Smith
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  4. Natalie Baecker
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Heer, M., Titze, J., Smith, S.M., Baecker, N. (2015). Fat-Soluble Vitamins. In: Nutrition Physiology and Metabolism in Spaceflight and Analog Studies. SpringerBriefs in Space Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-18521-7_5

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