Skip to main content

Early Cerebral Infarction after Aneurysmal Subarachnoid Hemorrhage

  • Chapter
Brain Edema XVI

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) is a serious disease with high case fatality and morbidity. Early cerebral infarction has been suggested as a risk factor for poor outcome. We aimed to assess the pattern of early and delayed cerebral infarction after aneurysmal subarachnoid hemorrhage. We prospectively enrolled consecutive aneurysmal subarachnoid hemorrhage (SAH) patients presenting to an academic neurosurgical referral center (Prince of Wales Hospital, the Chinese University of Hong Kong) in Hong Kong. Cerebral infarction occurred in 24 (48 %) patients, in which 14 (28 %) had early cerebral infarction and 14 (28 %) had delayed cerebral infarction. Early anterior cerebral infarction occurred in a similar proportion of anterior and posterior circulation aneurysms (24 % vs. 21 %), whereas posterior circulation aneurysm patients had a higher proportion of early posterior cerebral infarction compared with anterior circulation aneurysm patients (18 % vs. 2 %). In conclusion, early cerebral infarction was common and different from delayed cerebral infarction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Binaghi S, Colleoni ML, Maeder P, Uske A, Regli L, Dehdashti AR, Schnyder P, Meuli R (2007) CT angiography and perfusion CT in cerebral vasospasm after subarachnoid hemorrhage. AJNR Am J Neuroradiol 28:750–758

    CAS  PubMed  Google Scholar 

  2. Dorhout Mees SM, Algra A, Vandertop WP, van Kooten F, Kuijsten HA, Boiten J, van Oostenbrugge RJ, Al-Shahi Salman R, Lavados PM, Rinkel GJ, van den Bergh WM (2012) Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet 380:44–49

    Article  PubMed  Google Scholar 

  3. Juvela S, Siironen J (2012) Early cerebral infarction as a risk factor for poor outcome after aneurysmal subarachnoid haemorrhage. Eur J Neurol 19:332–339

    Article  CAS  PubMed  Google Scholar 

  4. Juvela S, Siironen J, Varis J, Poussa K, Porras M (2005) Risk factors for ischemic lesions following aneurysmal subarachnoid hemorrhage. J Neurosurg 102:194–201

    Article  PubMed  Google Scholar 

  5. Kivisaari RP, Salonen O, Servo A, Autti T, Hernesniemi J, Ohman J (2001) MR imaging after aneurysmal subarachnoid hemorrhage and surgery: a long-term follow-up study. AJNR Am J Neuroradiol 21:1143–1148

    Google Scholar 

  6. Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9:179–186

    Article  CAS  PubMed  Google Scholar 

  7. Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, Marr A, Roux S, Kassell N (2011) Clazosentan, an endothelial receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2). Lancet Neurol 10:618–625

    Article  CAS  PubMed  Google Scholar 

  8. Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, Nowbakht P, Roux S, Kassell N (2012) Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Stroke 43:1463–1469

    Article  CAS  PubMed  Google Scholar 

  9. Nieuwkamp DJ, Setz LE, ALgra A, Linn FHH, de Rooij NK, Rinkel GJ (2009) Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis. Lancet Neurol 8:635–642

    Article  PubMed  Google Scholar 

  10. Pallant J (2007) SPSS survival manual: a step by step guide to data analysis using SPSS for windows, 3rd edn. Open University Press/McGraw-Hill Education, Maidenhead/Berkshire

    Google Scholar 

  11. Pickard JD, Murray GD, Illingworth R, Shaw MD, Teasdale GM, Foy PM, Humphrey PR, Lang DA, Nelson R, Richards P, Sinar J, Bailey S, Skene A (1989) Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. Br Med J 298:636–642

    Article  CAS  Google Scholar 

  12. Rabinstein AA, Friedman JA, Weignan SD, McClelland RL, Fulgham JR, Manno EM, Atkinson JL, Wijdicks EF (2004) Predictors of cerebral infarction in aneurysmal subarachnoid hemorrhage. Stroke 35:1862–1866

    Article  PubMed  Google Scholar 

  13. Rankin L (1957) Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J 2:200–215

    CAS  PubMed  Google Scholar 

  14. Tong A, Man DW (2002) The validation of the Hong Kong Chinese version of the Lawton instrumental activities of daily living scale for institutionalized elderly persons. OTJR Occup Particip Health 22:132–142

    Google Scholar 

  15. Wong GK, Lam S, Ngai K, Wong A, Mok V, Poon WS, Cognitive Dysfunction after Aneurysmal Subarachnoid Haemorrhage Investigators (2012) Evaluation of cognitive impairment by the Montreal Cognitive Assessment in patients with aneurysmal subarachnoid haemorrhage: prevalence, risk factors, and correlations with 3 month outcome. J Neurol Neurosurg Psychiatry 83:1112–1117

    Article  PubMed  Google Scholar 

  16. Wong GK, Poon WS, Boet R, Chan MT, Gin T, Ng SC, Zee BC (2011) Health-related quality of life after aneurysmal subarachnoid hemorrhage: profile and clinical factors. Neurosurgery 68:1556–1561

    Article  PubMed  Google Scholar 

  17. Wong GK, Poon WS, Chan MT, Boet R, Gin T, Ng SC, Zee BC, Investigators IMASH (2010) Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage (IMASH): a randomized, double-blinded, placebo-controlled, multicenter phase III trial. Stroke 41:921–926

    Article  CAS  PubMed  Google Scholar 

  18. van Sieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn GJ (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19:604–607

    Article  Google Scholar 

  19. Vilkki JS, Juvela S, Siironen J, Ilvoen T, Varis J, Porras M (2004) Relationship of local infarctions to cognitive and psychosocial impairment after aneurysmal subarachnoid hemorrhage. Neurosurgery 55:790–803

    Article  PubMed  Google Scholar 

  20. Vergouwen MD, Ilodigwe D, Macdonald RL (2011) Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects. Stroke 42:924–929

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to George Kwok Chu Wong MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Wong, G.K.C. et al. (2016). Early Cerebral Infarction after Aneurysmal Subarachnoid Hemorrhage. In: Applegate, R., Chen, G., Feng, H., Zhang, J. (eds) Brain Edema XVI. Acta Neurochirurgica Supplement, vol 121. Springer, Cham. https://doi.org/10.1007/978-3-319-18497-5_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-18497-5_28

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18496-8

  • Online ISBN: 978-3-319-18497-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics