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Brain Edema XVI pp 127–130Cite as

Effects of Low-Dose Unfractionated Heparin Pretreatment on Early Brain Injury after Subarachnoid Hemorrhage in Mice

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 121))

Abstract

Heparin is a pleiotropic drug that antagonizes many pathophysiological mechanisms. In this study, we evaluated whether heparin prevents early brain injury (EBI) after subarachnoid hemorrhage (SAH) in mice. SAH was induced by endovascular perforation in mice randomly assigned to sham-operated (n = 8), SAH + vehicle (n = 12), SAH + 10 U heparin pretreatment (n = 11), and SAH + 30 U heparin pretreatment (n = 14) groups. At 24 h post-SAH, severity of SAH, neurological scores, and brain water content were evaluated. Low-dose heparin pretreatment improved neurobehavioral function, and decreased brain edema in the ipsilateral cerebral hemisphere to the perforation side. High-dose heparin had a tendency for increased SAH, which obscured the neuroprotective effects by heparin. Low-dose heparin pretreatment may decrease the development of post-SAH EBI.

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Conflict of Interest

The authors report no conflicts of interest.

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Authors and Affiliations

  1. Departments of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA, 92354, USA

    Orhan Altay MD, Hidenori Suzuki MD, PhD, Yu Hasegawa MD, PhD, Mehmet Sorar MD, Han Chen MD, Jiping Tang MD & John H. Zhang MD, PhD

  2. Departments of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John H. Zhang MD, PhD

Authors
  1. Orhan Altay MD
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  2. Hidenori Suzuki MD, PhD
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  3. Yu Hasegawa MD, PhD
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  4. Mehmet Sorar MD
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  5. Han Chen MD
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  6. Jiping Tang MD
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  7. John H. Zhang MD, PhD
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Corresponding author

Correspondence to John H. Zhang MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, California, USA

    Richard L. Applegate

  2. Department of Neurosurgery, Soochow University The First Affiliated Hospital, Suzhou, Jiangsu, China

    Gang Chen

  3. Department of Neurosurgery, Third Military Medical University Southwest Hospital, Chongqing, China

    Hua Feng

  4. Dept.of Anesthesiology, Physiology and Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, USA

    John H. Zhang

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© 2016 Springer International Publishing Switzerland

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Altay, O. et al. (2016). Effects of Low-Dose Unfractionated Heparin Pretreatment on Early Brain Injury after Subarachnoid Hemorrhage in Mice. In: Applegate, R., Chen, G., Feng, H., Zhang, J. (eds) Brain Edema XVI. Acta Neurochirurgica Supplement, vol 121. Springer, Cham. https://doi.org/10.1007/978-3-319-18497-5_22

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  • DOI: https://doi.org/10.1007/978-3-319-18497-5_22

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18496-8

  • Online ISBN: 978-3-319-18497-5

  • eBook Packages: MedicineMedicine (R0)

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