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Selective Expression of Galanin in Neuronal-Like Cells of the Human Carotid Body

  • Camillo Di Giulio
  • Guya Diletta Marconi
  • Susi Zara
  • Andrea Di Tano
  • Andrea Porzionato
  • Mieczyslaw Pokorski
  • Amelia Cataldi
  • Andrea MazzatentaEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 860)

Abstract

The carotid body is a neural-crest-derived organ devoted to respiratory homeostasis through sensing changes in blood oxygen levels. The sensory units are the glomeruli composed of clusters of neuronal-like (type I) cells surrounded by glial-like (type II) cells. During chronic hypoxia, the carotid body shows growth, with increasing neuronal-like cell numbers. We are interested in the signals involved in the mechanisms that underlie such response, because they are not well understood and described. Considering that, in literature, galanin is involved in neurotrophic or neuroprotective role in cell proliferation and is expressed in animal carotid body, we investigated its expression in human. Here, we have shown the expression and localisation of galanin in the human carotid body.

Keywords

Galanin Carotid body Hypoxia Oxygen sensing 

Notes

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Camillo Di Giulio
    • 1
  • Guya Diletta Marconi
    • 2
  • Susi Zara
    • 2
  • Andrea Di Tano
    • 1
  • Andrea Porzionato
    • 3
  • Mieczyslaw Pokorski
    • 4
    • 5
    • 6
  • Amelia Cataldi
    • 2
  • Andrea Mazzatenta
    • 1
    Email author
  1. 1.Department of Neurosciences, Imaging and Clinical ScienceUniversity ‘G. d’Annunzio’ of Chieti–PescaraChietiItaly
  2. 2.Department of PharmacologyUniversity ‘G. d’Annunzio’ of Chieti–PescaraChietiItaly
  3. 3.Section of Human Anatomy, Department of Molecular MedicineUniversity of PadovaPadovaItaly
  4. 4.Laboratory of ElectrophysiologyClinical Research Center, Murayama Medical CenterMusashiMurayama CityJapan
  5. 5.Public Higher Medical Professional SchoolOpolePoland
  6. 6.Institute of PsychologyOpole UniversityOpolePoland

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