The Association Between Antihypertensive Medication and Blood Pressure Control in Patients with Obstructive Sleep Apnea

  • Lucília N. DiogoEmail author
  • Paula Pinto
  • Cristina Bárbara
  • Ana L. Papoila
  • Emília C. Monteiro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 860)


Obstructive sleep apnea and hypertension are closely related diseases. The lowering effect of continuous positive airway pressure (CPAP) on blood pressure (BP) control is modest and concomitant antihypertensive therapy is still required. However, the best antihypertensive regimen for BP control in patients with OSA remains unknown. We aimed to investigate a hypothetical association between ongoing antihypertensive medication and BP control rates in patients with OSA. We conducted a prospective observational study in a cohort of 205 patients with OSA and hypertension who underwent a sleep study and 24-h ambulatory blood pressure monitoring (ABPM). Ongoing antihypertensive medication profile was recorded. Logistic regression models were used to investigate the association between antihypertensive regimen and BP control, before (n = 205) and, when applicable, after CPAP adaptation (n = 90). One hundred and fifty-five patients (155/205) were being treated with 31 different antihypertensive regimens. At baseline, the antihypertensive regimens and the number of antihypertensive drugs were not associated with BP control (p = 0.847; p = 0.991). After CPAP adaptation, a decrease in median night-time systolic and diastolic BP was observed (p = 0.001; p = 0.006). Nevertheless, the lack of association between antihypertensive regimens and the number of antihypertensive drugs and BP control remained (p = 0.864; p = 0.800). Our findings confirm that although CPAP improves nocturnal BP, this improvement is not sufficient to control blood pressure for 24 h. This study shows, for the first time, that in patients with OSA, there is no association between BP control and both the antihypertensive regimen and the number of antihypertensive drugs.


Ambulatory blood pressure monitoring Antihypertensive drugs Blood pressure Continuous positive airway pressure Hypertension and obstructive sleep apnea 



LND is supported by the Portuguese Fundação para a Ciência e a Tecnologia (FCT) fellowships (SFRH/BD/48335/2008; PTDC/SAU-TOX/112264/2009) and CEDOC (Chronic Diseases Research Centre, Lisbon, Portugal).


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Lucília N. Diogo
    • 1
    Email author
  • Paula Pinto
    • 2
  • Cristina Bárbara
    • 2
  • Ana L. Papoila
    • 1
    • 3
  • Emília C. Monteiro
    • 1
  1. 1.Centro de Estudos de Doenças Crónicas, CEDOC, NOVA Medical School/Faculdade de Ciências MédicasUniversidade Nova de LisboaLisbonPortugal
  2. 2.Serviço de Pneumologia IICentro Hospitalar Lisboa Norte (CHLN)-Hospital Pulido ValenteLisbonPortugal
  3. 3.CEAULLisbonPortugal

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