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Superoxide Dismutase (SOD) Genes and Aging in Drosophila

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Life Extension

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 3))

Abstract

Since their discovery by McCord and Fridovich the superoxide dismutase (SOD) enzymes have been of particular interest to the field of aging. The Drosophila SOD genes are required for normal oxidative stress resistance and life span, and have been targets for investigation of mechanisms of aging. The ability of SOD genes to affect Drosophila life span is dependent upon the genetic background, including the sex of the animal, as well as the dietary environment. There is increasing understanding of the role of the SODs in signaling pathways that modulate aging. The Cu/ZnSOD is important in linking diet to life span, and MnSOD can activate the mitochondrial unfolded protein response and increase life span. The SOD genes also modulate survival in Drosophila models of human disease. The conservation of SOD genes and functions in Drosophila combined with the availability of powerful genetic and transgenic technologies promises to keep Drosophila at the forefront of research on aging and the role of SOD.

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Acknowledgments

This work was supported by a grant from the Department of Health and Human Services (AG011833) and by pilot project funds from the Southern California Environmental Health Sciences Center (5P30ES007048).

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  1. Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089-2910, USA

    John Tower

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Editors and Affiliations

  1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Kievs'ka, Ukraine

    Alexander M. Vaiserman

  2. Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Komi Republic, Russia

    Alexey A. Moskalev

  3. Laboratory of Genome Variation, Institute of Molecular Genetics of RAS, Moscow, Russia

    Elena G. Pasyukova

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Tower, J. (2015). Superoxide Dismutase (SOD) Genes and Aging in Drosophila . In: Vaiserman, A., Moskalev, A., Pasyukova, E. (eds) Life Extension. Healthy Ageing and Longevity, vol 3. Springer, Cham. https://doi.org/10.1007/978-3-319-18326-8_3

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