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Hepatitis Virus Scientific Background: Epidemiology and Mechanism of Carcinogenesis of Hepatitis C Virus (HCV)

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Tropical Hemato-Oncology

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Abstract

Hepatitis C virus infects 170 million people around the world and is mostly transmitted through parenteral routes. Most infected individuals remain with detectable HCV RNA after 6 months of infection characterizing a chronic hepatitis. Some of these cases might evolve to liver cirrhosis and hepatocellular carcinoma. The increased risk of HCC development in HCV-infected patients arises from the development of liver fibrosis and cirrhosis as a result of chronic inflammation, but some viral proteins, such as core, E2, NS3, and NS5A, might also be involved in the oncogenic transformation.

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Acknowledgements

This work was supported by grants 2011/50562-0 from the São Paulo Research Foundation (FAPESP) and 443152/2014-4 from CNPq and from Alves de Queiroz Family Fund for Research. João Renato Rebello Pinho receives fellowship from CNPq (Bolsista de Produtividade em Pesquisa do CNPq – Nível 2).

Author information

Authors and Affiliations

  1. Laboratório de Gastroenterologia e Hepatologia Tropical, “João Alves de Queiroz and Castorina Bittencourt Alves”, LIM-07, Instituto de Medicina Tropical, Prédio II 2 andar, São Paulo-SP, Brazil

    João Renato Rebello Pinho & Fernanda de Mello Malta

  2. Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, Av Dr Enéas de Carvalho Aguiar, 500, São Paulo-SP, 05403-000, Brazil

    João Renato Rebello Pinho & Fernanda de Mello Malta

  3. Albert Einstein Medicina Diagnóstica, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701, São Paulo-SP, 05651-901, Brazil

    João Renato Rebello Pinho

Authors
  1. João Renato Rebello Pinho
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  2. Fernanda de Mello Malta
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Corresponding author

Correspondence to João Renato Rebello Pinho .

Editor information

Editors and Affiliations

  1. Medical Oncology, Claude-Bernard-Lyon1 University, Lyon, France

    Jean-Pierre Droz

  2. Centre Hospitalier de Cayenne, Cayenne, French Guiana

    Bernard Carme

  3. Service de dermatologie, Centre hospitalier de Cayenne, Cayenne, French Guiana

    Pierre Couppié

  4. Guyane, INSERM CIC 1424, Centre d'Investigation Clinique Antilles, Centre Hospitalier de Cayenne, Cayenne, French Guiana

    Mathieu Nacher

  5. Service d’hémato-oncologie, Hôpital Saint-Louis, Paris, France

    Catherine Thiéblemont

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Pinho, J.R.R., de Mello Malta, F. (2015). Hepatitis Virus Scientific Background: Epidemiology and Mechanism of Carcinogenesis of Hepatitis C Virus (HCV). In: Droz, JP., Carme, B., Couppié, P., Nacher, M., Thiéblemont, C. (eds) Tropical Hemato-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-18257-5_14

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  • DOI: https://doi.org/10.1007/978-3-319-18257-5_14

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-18256-8

  • Online ISBN: 978-3-319-18257-5

  • eBook Packages: MedicineMedicine (R0)

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