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H2S: A New Approach to Lifespan Enhancement and Healthy Ageing?

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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 230))

Abstract

Ageing, a progressive structural and functional decline, is considered to be a major risk factor for virtually all ageing-associated pathologies and disabilities, including Alzheimer’s disease, Parkinson’s disease, stroke, diabetes, atherosclerosis and certain cancers. Biogerontology research has now been largely directed towards finding novel drug targets to decelerate the ageing process and attain healthy ageing in order to delay the onset of all ageing-related diseases. H2S has been reported to exert vasodilatory, antioxidant, antiapoptotic and anti-inflammatory actions and has been shown to act as a signalling molecule, neuromodulator and cytoprotectant. Intriguingly, H2S has been reported to regulate cell cycle and survival in healthy cells which suggests that it may regulate cell fate and hence the ageing process. This chapter sets out to provide an overview of the current knowledge regarding the involvement of H2S in ageing, with a specific focus on the invertebrate model nematode C. elegans.

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Authors and Affiliations

  1. MRC-HPA Centre for Environment and Health, Analytical and Environmental Sciences Division, Faculty of Life Sciences and Medicine, King’s College London, 150 Stamford Street, London, SE1 9NH, UK

    Bedoor Qabazard & Stephen R. Stürzenbaum

  2. Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait City, Kuwait

    Bedoor Qabazard

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  1. Bedoor Qabazard
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  2. Stephen R. Stürzenbaum
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Correspondence to Stephen R. Stürzenbaum .

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  1. National University of Singapore, Singapore, Singapore

    Philip K. Moore

  2. ST. Luke's Campus, University of Exeter Medical School, Exeter, United Kingdom

    Matt Whiteman

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Qabazard, B., Stürzenbaum, S.R. (2015). H2S: A New Approach to Lifespan Enhancement and Healthy Ageing?. In: Moore, P., Whiteman, M. (eds) Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide. Handbook of Experimental Pharmacology, vol 230. Springer, Cham. https://doi.org/10.1007/978-3-319-18144-8_14

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