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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide pp 243–265Cite as

Role of H2S Donors in Cancer Biology

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 230))

Abstract

Hydrogen sulfide (H2S) donors including organosulfur compounds (OSC), inorganic sulfide salts, and synthetic compounds are useful tools in studies to elucidate the effects of H2S in cancer biology. Studies using such donors have shown the ability of H2S to suppress tumor growth both in vitro and in vivo, with some of them suggesting the selectivity of its cytotoxic effects to cancer cells. In addition to promoting cancer cell death, H2S donors were also found to inhibit cancer angiogenesis and metastasis. The underlying mechanisms for the anticancer activities of H2S involve (1) cell signaling pathways, such as MAPK and STAT; (2) cell cycle regulation; (3) microRNAs regulation; and (4) cancer metabolism and pH regulation. Altogether, compiling evidences have demonstrated the great potential of using H2S donors as anticancer agents. Nevertheless, the application and development of H2S for therapy are still facing challenges as identification of molecular targets of H2S awaits further investigation.

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Authors and Affiliations

  1. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore

    Zheng-Wei Lee & Lih-Wen Deng

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  1. Zheng-Wei Lee
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  2. Lih-Wen Deng
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Correspondence to Lih-Wen Deng .

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  1. National University of Singapore, Singapore, Singapore

    Philip K. Moore

  2. ST. Luke's Campus, University of Exeter Medical School, Exeter, United Kingdom

    Matt Whiteman

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Lee, ZW., Deng, LW. (2015). Role of H2S Donors in Cancer Biology. In: Moore, P., Whiteman, M. (eds) Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide. Handbook of Experimental Pharmacology, vol 230. Springer, Cham. https://doi.org/10.1007/978-3-319-18144-8_13

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