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Biomaterials-Based Immunomodulation of Dendritic Cells

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Biomaterials in Regenerative Medicine and the Immune System

Abstract

Modulation of the immune system through the use of biomaterials provides opportunities for new applications in the field of regenerative medicine to be translated into clinical settings. Particularly, biomaterials-based immunomodulation targeting dendritic cells has gained much interest in recent years. Dendritic cells are professional antigen-presenting cells serving as the bridge between innate and adaptive immunity, and they capture, process, and present antigen to naïve T cells to further dictate immune response outcomes. Current biomaterials-based technologies targeting dendritic cells have focused on inducing either inflammatory or suppressive phenotypes through the use of particulates or scaffolds, the modulation of material properties, and the delivery of proteins, nucleic acids, and small drug molecules. This chapter provides relevant immunology concepts, an overview of dendritic cells and their functions, and highlights exciting new biomaterials-based techniques employed for use in cancer, infectious and autoimmune diseases, and transplant rejection.

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Authors and Affiliations

  1. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. BMS J291, PO Box 116131, Gainesville, FL, USA

    Evelyn Bracho-Sanchez, Jamal S. Lewis & Benjamin G. Keselowsky

Authors
  1. Evelyn Bracho-Sanchez
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  2. Jamal S. Lewis
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  3. Benjamin G. Keselowsky
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Corresponding author

Correspondence to Evelyn Bracho-Sanchez .

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Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Laura Santambrogio

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Bracho-Sanchez, E., Lewis, J., Keselowsky, B. (2015). Biomaterials-Based Immunomodulation of Dendritic Cells. In: Santambrogio, L. (eds) Biomaterials in Regenerative Medicine and the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-18045-8_8

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