Abstract
Occupational exposure to pollution may accelerate or even induce the onset of diseases. A pecuniary compensation, to be paid by the state or the company, is then due to the exposed workers. The computation of the amount of this compensation might be based on the so-called “expected number of years of disease-free life” lost by the workers due to their occupational exposure. In order to estimate this number of years, we propose a method based on the threshold regression model also known as first hitting time (FHT) model. This model was initially developed for cohort studies. As our motivating example is a case-control study conducted in France to evaluate the link between lung cancer occurrence and occupational exposure to asbestos, we define a FHT model, adapt it to case-control data, and finally derive, for each worker in the study, the estimated expected number of years of disease-free life lost due to their occupational exposure to asbestos.
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References
Chambaz, A., Choudat, D., Huber-Carol, C., Pairon, J.-C., van der Laan, M.J.: Analysis of the effect of occupational exposure to asbestos based on threshold regression modeling of case-control data. Biostatistics 15(2), 327–340 (2014)
Hall, P.: The Bootstrap and Edgeworth Expansion. Springer Series in Statistics. Springer, New York (1992)
Hochberg, Y.: A sharper Bonferroni procedure for multiple tests of significance. Biometrika 75, 800–803 (1988)
Holm, S.: A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6, 65–70 (1979)
Hommel, G.: A stagewise rejective multiple test procedure based on a modified Bonferroni test. Biometrika 75, 383–386 (1988)
Lee, M.-L.T., Whitmore, G.A.: Threshold regression for survival analysis: modeling event times by a stochastic process reaching a boundary. Stat. Sci. 21(4), 501–513 (2006)
Lee, M.-L.T., Whitmore, G.A.: Proportional hazards and threshold regression: their theoretical and practical connections. Lifetime Data Anal. 16(2), 196–214 (2010)
Pairon J.-C., Legal-Regis B., Ameille J., Brechot J.-M., Lebeau B., Valeyre D., Monnet I., Matrat M., and Chammings B., Housset S.: Occupational lung cancer: a multicentric case-control study in Paris area. European Respiratory Society, 19th Annual Congress. Vienna (2009)
Shaffer, J.P.: Multiple hypothesis testing. Annu. Rev. Psychol. 46, 561–576 (1995)
Wright, S.P.: Adjusted P-values for simultaneous inference. Biometrics 48, 1005–1013 (1992)
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Chambaz, A., Choudat, D., Huber-Carol, C. (2015). Acceleration, Due to Occupational Exposure, of Time to Onset of a Disease. In: Kitsos, C., Oliveira, T., Rigas, A., Gulati, S. (eds) Theory and Practice of Risk Assessment. Springer Proceedings in Mathematics & Statistics, vol 136. Springer, Cham. https://doi.org/10.1007/978-3-319-18029-8_5
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DOI: https://doi.org/10.1007/978-3-319-18029-8_5
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