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Host Genomics and Response to Infectious Agents

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Genomics, Personalized Medicine and Oral Disease

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Abstract

Most adults are latently and life-long infected by Herpes simplex virus type I (HSV-1), which causes common, and usually mild, diseases of the orofacial skin and mucous membranes, including herpes labialis (cold sores) and gingivostomatitis. However, many infected individuals never experience any symptoms. On the contrary, some patients suffer disturbingly frequent recurrences, which reflect incapacity of the immune system to avoid virus reactivation from latent infection. Furthermore, HSV-1 can cause infections of greater clinical consequence, such as those affecting the central nervous system or the eye. This variability in the control of the widespread HSV-1 infection has intrigued physicians and scientists since decades ago but it remains largely unexplained. Here we review recent contributions to knowledge on defence against herpetic infection and the relationship between diversity of the human genome and variable susceptibility to disease caused by HSV-1, as a model of oral chronic infection.

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Acknowledgements

We thank Dr. Miguel López-Botet (Universitat Pompeu Fabra, Barcelona, Spain) for comments on the manuscript and continued scientific advice. Manuela Moraru is currently supported by a grant (121532) from Fundació La Marató TV3, Barcelona. Our studies on genetics of the immune response to HSV-1 were successively supported by grants from Instituto de Salud Carlos III and Plan Nacional de I + D, Spain (SAF2010-22153-C03-03, BFU2005-04622, and FIS01/0381).

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  1. Immunogenetics & Histocompatibility, Instituto de Investigación Sanitaria Puerta de Hierro, Manuel de Falla1, 28222, Majadahonda, Spain

    Manuela Moraru & Carlos Vilches

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  1. Manuela Moraru
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  2. Carlos Vilches
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Correspondence to Carlos Vilches .

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  1. Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Stephen T. Sonis, DMD, DMSc

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Moraru, M., Vilches, C. (2015). Host Genomics and Response to Infectious Agents. In: Sonis, DMD, DMSc, S. (eds) Genomics, Personalized Medicine and Oral Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-17942-1_4

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