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Surgical Approaches to Early-Stage Renal Cell Carcinoma

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Kidney Cancer

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Abstract

With the increased use of cross-sectional imaging, the incidence of early-stage localized renal cell carcinoma (RCC) or the small renal mass continues to rise. Treatment options for localized RCC include surgical excision, ablative techniques, and active surveillance. All treatment paradigms have excellent short-term, intermediate-term, long-term, and, when available, oncologic outcomes. Each technique offers various advantages and disadvantages compared to the other treatment alternatives. Due to the success of the various treatment approaches, the decision to treat a particular patient with localized RCC in a certain manner is relatively subjective and based on practitioner and patient biases. Considering recent data that has questioned the utility of active intervention for localized RCC, especially in the elderly, attempts have been made to quantify the risk/benefit of treatment. Also, reproducible measures of renal tumor anatomy and the refinement of the measurement of renal function have been created and advocated to more accurately assess the oncologic risk of localized RCC against the risks of treatment-related adverse events and chronic kidney disease. In this chapter, we review the existing treatment options for localized RCC contextualized against the risks of competing health comorbidities and chronic kidney disease. Furthermore, we discuss the utility of reproducible, objective methods to preoperatively define salient renal mass anatomy and how this can potentially objectify treatment decision making. Finally, in this chapter, we attempt to provide a standardized platform whereby the treatment decision-making process for localized RCC accounts for all the available objective data in order to arrive at the optimal treatment decision for each individual patient based on the risks and benefits of treatment.

This work was supported in part by Fox Chase Cancer Center via institutional support of the Kidney Cancer Keystone Program.

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Authors and Affiliations

  1. Department of Urology, Einstein Healthcare Network, Philadelphia, PA, USA

    Daniel J. Canter MD, David B. Cahn DO & Robert G. Uzzo MD (Chairman)

  2. Department of Urologic Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA

    Daniel J. Canter MD & Robert G. Uzzo MD (Chairman)

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  1. Daniel J. Canter MD
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  2. David B. Cahn DO
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Correspondence to Robert G. Uzzo MD .

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Editors and Affiliations

  1. Department of Internal Medicine, Division of Hematology - Oncology, University of California Davis, School of Medicine UC Davis Comprehensive Cancer center, Sacramento, California, USA

    Primo N. Lara

  2. Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Eric Jonasch

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Canter, D.J., Cahn, D.B., Uzzo, R.G. (2015). Surgical Approaches to Early-Stage Renal Cell Carcinoma. In: Lara, P., Jonasch, E. (eds) Kidney Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-17903-2_9

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