Abstract
Clinicians have long suspected that significant heterogeneity may exist within individual tumors and their metastases. Patients with metastatic renal cell cancer (RCC) are known to develop mixed responses to therapy suggesting the presence of tumor subclones and clonal selection. Advances in laboratory techniques – including next generation sequencing – have provided new means of understanding RCC intra tumor heterogeneity and clomal evolution. This chapter briefly summarizes the state-of-the-art in RCC hetero geneity research and highlights potential clinical implicatiuons.
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Sun, D., Jonasch, E., Lara, P.N. (2015). Genetic Heterogeneity of Kidney Cancer. In: Lara, P., Jonasch, E. (eds) Kidney Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-17903-2_5
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DOI: https://doi.org/10.1007/978-3-319-17903-2_5
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-17902-5
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