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Toxicity Management of Renal Cell Cancer Patients on Targeted Therapies

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Kidney Cancer

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Abstract

Targeted therapies have significantly changed the treatment landscape for patients with metastatic renal cell carcinoma (mRCC). TKIs such as sunitinib, sorafenib, pazopanib, and axitinib are all multi-targeted inhibitors which inhibit a variety of targets including the vascular endothelial growth factor receptors 1, 2, and 3, platelet-derived growth factor receptor (PDGFR), and others. Temsirolimus and everolimus both interfere with angiogenesis by inhibiting mTOR, a critical regulator within the cell. Bevacizumab blocks the vascular endothelial growth factor (VEGF) pathway by binding to VEGF.

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Authors and Affiliations

  1. Division of Medical Oncology, British Columbia Cancer Agency Vancouver Cancer Centre, 600 West 10th Avenue, Vancouver, BC, V5Z 4E6, Canada

    Christian Kollmannsberger MD, FRCPC

  2. Department of Medical Oncology, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada

    G. A. Bjarnason

  3. Department of Medical Oncology, Bordeaux University Victor Segalen, Bordeaux, France

    Alain Ravaud

  4. Hôpital Saint André, University Hospital, Bordeaux, France

    Alain Ravaud

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  1. Christian Kollmannsberger MD, FRCPC
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  2. G. A. Bjarnason
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  3. Alain Ravaud
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Correspondence to Christian Kollmannsberger MD, FRCPC .

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Editors and Affiliations

  1. Department of Internal Medicine, Division of Hematology - Oncology, University of California Davis, School of Medicine UC Davis Comprehensive Cancer center, Sacramento, California, USA

    Primo N. Lara

  2. Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Eric Jonasch

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Kollmannsberger, C., Bjarnason, G.A., Ravaud, A. (2015). Toxicity Management of Renal Cell Cancer Patients on Targeted Therapies. In: Lara, P., Jonasch, E. (eds) Kidney Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-17903-2_22

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