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Impact of Genetic Background in Otitis Media Predisposition

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Otitis Media: State of the art concepts and treatment

Abstract

Predisposition to the development of otitis media (OM) results from a complex interaction between patient and environmental factors. Heritability studies done in twins have demonstrated a strong genetic component to both acute and chronic OM. Three separate genome-wide linkage scan studies have identified potentially important chromosomal regions that are associated with OM susceptibility. Candidate genes that have been considered to potentially play a role in OM susceptibility include toll-like receptors, the TGF-β signaling pathway, surfactants, and mucins. Specific genes that have been shown to be highly correlated to middle ear disease in both humans and animal models include TLR4, and FBXO11. This chapter reviews what is known regarding the influence of specific genetic factors on the development of OM.

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Author information

Authors and Affiliations

  1. Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Shannon Fraser MD & Margaretha L. Casselbrant

  2. Departments of Surgery and Microbiology, Allegheny General Hospital, Pittsburgh, PA, USA

    J. Christopher Post

  3. Temple University School of Medicine and Drexel University College of Medicine, Pittsburgh, PA, USA

    J. Christopher Post

  4. Division of Pediatric Otolaryngology, Children’s Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Faculty Pavillion, 7th Floor, Pittsburgh, Pittsburgh, PA, 15224, USA

    Margaretha L. Casselbrant

Authors
  1. Shannon Fraser MD
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  2. J. Christopher Post
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  3. Margaretha L. Casselbrant
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Corresponding author

Correspondence to Margaretha L. Casselbrant .

Editor information

Editors and Affiliations

  1. Department of Pediatric Otolaryngology, Childrens National Medical Center, Washington, District of Columbia, USA

    Diego Preciado

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Fraser, S., Post, J., Casselbrant, M. (2015). Impact of Genetic Background in Otitis Media Predisposition. In: Preciado, D. (eds) Otitis Media: State of the art concepts and treatment. Springer, Cham. https://doi.org/10.1007/978-3-319-17888-2_3

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  • DOI: https://doi.org/10.1007/978-3-319-17888-2_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17887-5

  • Online ISBN: 978-3-319-17888-2

  • eBook Packages: MedicineMedicine (R0)

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