Abstract
Acrodermatitis Enteropathica symptoms usually begin to appear either within the first few days of life in formula fed infants or immediately upon discontinuation of breastfeeding [1]. Appearance of symptoms after change from breast milk to bovine milk indicates that human milk has a protective role which may be due to presence of low molecular binding agents that increase zinc bioavailability [2]. Common early symptoms of AE include the appearance of perleche (angular chelitis), skin lesions, erythematous patches, plaques of dry and scaly skin, and eczematous plaques on the face, scalp, and genital area: these skin dermatitises deteriorate quickly [1]. The lesions gradually begin emerging inside the mouth and then on the hands and feet, accompanied by Paronychia and inflammatory dermatitis on the palms, wrinkles on fingers, as well as scaly skin on the neck [3]. Next, diarrhea is one of the most variable symptoms of AE. If it appears and is exacerbated, it could lead to dehydration and loss of essential minerals and electrolytes; which could result in complications with the clinical treatment [1].
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Van Wouwe JP. Clinical and laboratory diagnosis of acrodermatitis enteropathica. Eur J Pediatr. 1989;149(1):2–8.
Arnaud J, Favier A. Determination of ultrafilterable zinc in human milk by electrothermal atomic absorption spectrometry. Analyst. 1992;117(10):1593–8.
Maverakis E, et al. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol. 2007;56(1):116–24.
Gehrig KA, Dinulos JG. Acrodermatitis due to nutritional deficiency. Curr Opin Pediatr. 2010;22(1):107–12.
Seyhan ME, et al. Acrodermatitis enteropathica-like eruptions in a child with Hartnup disease. Pediatr Dermatol. 2006;23(3):262–5.
Sehgal VN, Jain S. Acrodermatitis enteropathica. Clin Dermatol. 2000;18(6):745–8.
Puri N. A study of efficacy of oral zinc therapy for acrodermatitis enteropathica. Nasza Dermatolologia Online. 2013;4:162–6.
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Beigi, P.K.M., Maverakis, E. (2015). Clinical Symptoms. In: Acrodermatitis Enteropathica. Springer, Cham. https://doi.org/10.1007/978-3-319-17819-6_4
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DOI: https://doi.org/10.1007/978-3-319-17819-6_4
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-17818-9
Online ISBN: 978-3-319-17819-6
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