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History of Acrodermatitis Enteropathica

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Acrodermatitis Enteropathica

Abstract

Acrodermatitis Enteropathica (AE) is an inherited autosomal recessive disorder which often presents in newborn infants [1]. This medical condition occurs as a result of mutation of a zinc transporter that affects the uptake of zinc in the intestine causing a decrease in the level of this elemental mineral in the blood [2]. Prior to this knowledge, untreated AE was considered deleterious to the infant’s health and sometimes even fatal [3, 4]. Today however, the treatment involves adding zinc supplements to the patient’s diet which can easily improve the condition [1, 3].

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References

  1. Maverakis E, et al. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol. 2007;56(1):116–24.

    Article  PubMed  Google Scholar 

  2. Puri N. A study of efficacy of oral zinc therapy for acrodermatitis enteropathica. Nasza dermatolologia online. 2013;4:162–6.

    Article  Google Scholar 

  3. Van Wouwe JP. Clinical and laboratory diagnosis of acrodermatitis enteropathica. Eur J Pediatr. 1989;149(1):2–8.

    Article  PubMed  Google Scholar 

  4. Aggett PJ. Acrodermatitis enteropathica. J Inherit Metab Dis. 1983;6 Suppl 1:39–43.

    Article  PubMed  Google Scholar 

  5. Wende GW. Epidermolysis bullosa hereditaria. J Cut Dis. 1902;20:537–47.

    Google Scholar 

  6. Brandt T. Dermatitis in children with disturbances of the general condition and the absorption of food elements. Acta Derm. 1936;17:513–46.

    Google Scholar 

  7. Danbolt N, Closs K. Acrodermatitis enteropathica. Acta Derm Venerol. 1942;23:127–69.

    Google Scholar 

  8. Neldner KH, Hambidge KM. Zinc therapy of acrodermatitis enteropathica. N Engl J Med. 1975;292(17):879–82.

    Article  CAS  PubMed  Google Scholar 

  9. Moynahan EJ. Letter: acrodermatitis enteropathica: a lethal inherited human zinc-deficiency disorder. Lancet. 1974;2(7877):399–400.

    Article  CAS  PubMed  Google Scholar 

  10. Aggett PJ, et al. The therapeutic effect of amphotericin in acrodermatitis enteropathica: hypothesis and implications. Eur J Pediatr. 1981;137(1):23–5.

    Article  CAS  PubMed  Google Scholar 

  11. Hurley LS, et al. Zinc-binding ligands in milk and intestine: a role in neonatal nutrition? Proc Natl Acad Sci U S A. 1977;74(8):3547–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Evans GW, Johnson PE. Characterization and quantitation of a zinc-binding ligand in human milk. Pediatr Res. 1980;14(7):876–80.

    Article  CAS  PubMed  Google Scholar 

  13. Küry S, et al. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet. 2002;31(3):239–40.

    Article  PubMed  Google Scholar 

  14. Wang K, et al. Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. Am J Hum Genet. 2001;68(4):1055–60.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Beigi, P.K.M., Maverakis, E. (2015). History of Acrodermatitis Enteropathica. In: Acrodermatitis Enteropathica. Springer, Cham. https://doi.org/10.1007/978-3-319-17819-6_1

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  • DOI: https://doi.org/10.1007/978-3-319-17819-6_1

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17818-9

  • Online ISBN: 978-3-319-17819-6

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