Abstract
Epilepsy surgery is undoubtedly effective in reducing seizure frequency, and in many cases stopping seizures, in carefully selected children with drug-resistant epilepsy. However, seizure control clearly is not the only outcome from epilepsy surgery, and there are other outcomes which are arguably more important in some children including improved development, behavior, and quality of life.
Mental health problems are common in children with epilepsy (CWE), and are very frequently seen in children undergoing epilepsy surgery. Following surgery, there can be improvements in the mental health of some children, but there are others for whom there is no improvement, or indeed deterioration in their preexisting psychiatric symptoms. Furthermore, there are children who develop new psychiatric problems postoperatively. In this chapter, mental health problems in children undergoing epilepsy surgery will be reviewed and psychiatric outcome considered, with particular emphasis on what is known about long-term outcomes.
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McDermott S, Mani S, Krishnaswami S. A population- based analysis of specific behavior problems associated with childhood seizures. J Epilepsy. 1995;8:110–8.
Rutter M, Graham P, Yule W. A neuropsychiatric study in childhood. In: Clinics in developmental medicine, vol. 35/36. London: Heinemann; 1970.
Davies S, Heyman I, Goodman R. A population survey of mental health problems in children with epilepsy. Dev Med Child Neurol. 2003;45:292–5.
Davies S, Heyman I. Psychiatric aspects. In: Wallace SJ, Farrell K, editors. Epilepsy in children. London: Arnold; 2004. p. 447–62.
Devlin AM, Cross JH, Harkness W, Chong WK, Harding B, Vargha-Khadem F, Neville BG. Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence. Brain. 2003;126(Pt 3):556–66.
Salpekar JA, Berl MM, Havens K, Cushner-Weinstein S, Conry JA, Pearl PL, Yaun AL, Gaillard WD. Psychiatric symptoms in children prior to epilepsy surgery differ according to suspected seizure focus. Epilepsia. 2013;54(6):1074–82.
Danielsson S, Rydenhag B, Uvebrant P, Nordborg C, Olsson I. Temporal lobe resections in children with epilepsy: neuropsychiatric status in relation to neuropathology and seizure outcome. Epilepsy Behav. 2002;3(1):76–81.
McLellan A, Davies S, Heyman I, Harding B, Harkness W, Taylor D, Neville BG, Cross JH. Psychopathology in children with epilepsy before and after temporal lobe resection. Dev Med Child Neurol. 2005;47(10):666–72.
Lendt M, Helmstaedt C, Kuczaty S, Schramm J, Elger C. Behavioural disorders in children with epilepsy: early improvement after surgery. J Neurol Neurosurg Psychiatry. 2000;69(6):739–44.
Danielsson S, Viggedal G, Steffenburg S, Rydenhag B, Gillberg C, Olsson I. Psychopathology, psychosocial functioning, and IQ before and after epilepsy surgery in children with drug-resistant epilepsy. Epilepsy Behav. 2009;14(2):330–7.
Penfield W, Jaspar HH. Epilepsy and the functional anatomy of the human brain. Boston: Little, Brown; 1954. p. 841–2.
Hermann B, Seidenberg M. Executive system dysfunction in temporal lobe epilepsy: effects of nociferous cortex versus hippocampal pathology. J Clin Exp Neuropsychol. 1995;17(6):809–19.
Shields WD. Effects of epilepsy surgery on psychiatric and behavioral comorbidities in children and adolescents. Epilepsy Behav. 2004;5 Suppl 3:S18–24.
Blumer D, Wakhlu S, Davies K, Hermann B. Psychiatric outcome of temporal lobectomy for epilepsy: incidence and treatment of psychiatric complications. Epilepsia. 1998;39(5):478–86.
Macrodimitris S, Sherman EM, Forde S, Tellez-Zenteno JF, Metcalfe A, Hernandez-Ronquillo L, Wiebe S, Jetté N. Psychiatric outcomes of epilepsy surgery: a systematic review. Epilepsia. 2011;52(5):880–90.
Smith ML, Elliott IM, Lach L. Cognitive, psychosocial, and family function one year after pediatric epilepsy surgery. Epilepsia. 2004;45(6):650–60.
Colonnelli MC, Cross JH, Davies S, D’Argenzio L, Scott RC, Pickles A, Hannan S, Harkness W, Heyman I. Psychopathology in children before and after surgery for extratemporal lobe epilepsy. Dev Med Child Neurol. 2012;54(6):521–6.
Besag FM. Psychopathological outcome of extratemporal lobe surgery: the need for international collaboration on data collection. Dev Med Child Neurol. 2012;54(6):486.
Sinclair DB, Aronyk K, Snyder T, McKean JD, Wheatley M, Gross D, Bastos A, Ahmed SN, Hao C, Colmers W. Extratemporal resection for childhood epilepsy. Pediatr Neurol. 2004;30(3):177–85.
Wilson PJ. Cerebral hemispherectomy for infantile hemiplegia. A report of 50 cases. Brain. 1970;93(1):147–80.
Pulsifer MB, Brandt J, Salorio CF, Vining EP, Carson BS, Freeman JM. The cognitive outcome of hemispherectomy in 71 children. Epilepsia. 2004;45(3):243–54.
Yonekawa T, Nakagawa E, Takeshita E, Inoue Y, Inagaki M, Kaga M, Sugai K, Sasaki M, Kaido T, Takahashi A, Otsuki T. Effect of corpus callosotomy on attention deficit and behavioral problems in pediatric patients with intractable epilepsy. Epilepsy Behav. 2011;22(4):697–704.
Cendes F, Ragazzo PC, da Costa V, Martins LF. Corpus callosotomy in treatment of medically resistant epilepsy: preliminary results in a pediatric population. Epilepsia. 1993;34(5):910–7.
Maehara T, Shimizu H. Surgical outcome of corpus callosotomy in patients with drop attacks. Epilepsia. 2001;42:67–71.
Yang TF, Wong TT, Kwan SY, Chang KP, Lee YC, Hsu TC. Quality of life and life satisfaction in families after a child has undergone corpus callosotomy. Epilepsia. 1996;37(1):76–80.
Gilliam F, Wyllie E, Kotagal P, Geckler C, Rusyniak G. Parental assessment of functional outcome following corpus callosotomy. Epilepsia. 1996;37:535–75.
Harvey AS, Freeman JL, Berkovic SF, Rosenfeld JV. Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Epileptic Disord. 2003;5(4):257–65.
Fohlen M, Lellouch A, Delalande O. Hypothalamic hamartoma with refractory epilepsy: surgical procedures and results in 18 patients. Epileptic Disord. 2003;5(4):267–73.
Spencer S, Huh L. Outcomes of epilepsy surgery in adults and children. Lancet Neurol. 2008;7:525–37.
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McLellan, A. (2015). Long-Term Psychiatric and Behavior Outcomes in Children Following Epilepsy Surgery. In: Malmgren, K., Baxendale, S., Cross, J. (eds) Long-Term Outcomes of Epilepsy Surgery in Adults and Children. Springer, Cham. https://doi.org/10.1007/978-3-319-17783-0_8
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DOI: https://doi.org/10.1007/978-3-319-17783-0_8
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