Abstract
Knee osteoarthritis (OA) is a multifactorial disease, and OA cases are affected by both genetics and environment to varying degrees. Knee OA is one of the leading causes of global disability. Idiopathic OA is the most common form of arthritis with still unknown pathogenic etiology and considerable contribution of genetic factors. One of the mechanisms of cartilage degradation in OA is enzymatic proteolysis of the extracellular matrix by metalloproteinases. MMP-1, produced by chondrocytes and synovial cells, is a major proteinase of the MMP family. Five phenotypes of knee OA have been identified: “minimal joint disease phenotype,” “strong muscle strength phenotype,” “severe radiographic OA phenotype,” “obese phenotype,” and “depressive mood phenotype.” Knees with degenerative changes in the medial compartment constituted the majority of cases (63 %). The average age of patients is 72 years for those with varus disease, 79 years for those with valgus disease, and 84 years for those with patellofemoral arthritis (PFA). Bilateral involvement was common only in patients with PFA (79 %). There is a female predominance in valgus and patellofemoral disease.
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References
Valdes A (2010) Genetic markers of osteoarthritis. Curr Rheumatol Rev 6:257–267
Turkiewicz A, Petersson IF, Björk J, Hawker G, Dahlberg LE, Lohmander LS et al (2014) Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032. Osteoarthritis Cartilage 22:1826–1832
Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M et al (2014) The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis 73:1323–1330
Teichtahl A, Wluka A, Wang Y, Jones G, Ding C, Cicuttini F (2010) Identification of early knee osteoarthritis – a new horizon. Curr Rheumatol Rev 6:251–256
Rolauffs B, Rothdiener M, Bahrs C, Badke A, Weise K, Kuettner KE et al (2011) Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis. Arthritis Rheum 63:1637–1647
Lepetsos P, Pampanos A, Kanavakis E, Tzetis M, Korres D, Papavassiliou AG et al (2014) Association of MMP-1–1607 1G/2G (rs1799750) polymorphism with primary knee osteoarthritis in the Greek population. J Orthop Res 32:1155–1160
Wassilew GI, Lehnigk U, Duda GN, Taylor WR, Matziolis G, Dynybil C (2010) The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders. Arthroscopy 26:1096–1104
Rodriguez-Fontenla C, Calaza M, Evangelou E, Valdes AM, Arden N, Blanco FJ et al (2014) Assessment of OA candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol 66:940–949
van der Esch M, Knoop J, van der Leeden M, Roorda LD, Lems WF, Knol DL et al (2015) Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort. Osteoarthritis Cartilage. pii: S1063–4584(15)00019-9. doi:10.1016/j.joca.2015.01.006. [Epub ahead of print]
Pan F, Khan H, Ding C, Winzenberg T, Martel-Pelletier J, Pelletier JP et al (2015) Familial effects on structural changes relevant to knee osteoarthritis: a prospective cohort study. Osteoarthritis Cartilage. pii:S1063–4584(15)00007-2. doi:10.1016/j.joca.2015.01.004. [Epub ahead of print]
Collins JE, Katz JN, Dervan EE, Losina E (2014) Trajectories and risk profiles of pain in persons with radiographic, symptomatic knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage 22:622–630
Barrett JP Jr, Rashkoff E, Sirna EC, Wilson A (1990) Correlation of roentgenographic patterns and clinical manifestations of symptomatic idiopathic osteoarthritis of the knee. Clin Orthop Relat Res 253:179–183
Gouttebarge V, Inklaar H, Backx F, Kerkhoffs G (2015) Prevalence of osteoarthritis in former elite athletes: a systematic overview of the recent literature. Rheumatol Int 35:405–418
Rodríguez-Merchán EC, Durán D, Revilla C, Gómez-Cardero P, Martínez-Lloreda A, Bello S (2014) Arthroscopic BPTB graft reconstruction in ACL ruptures: 15-year results and survival. Knee 21:902–905
Rodríguez-Merchán EC (1998) Management of the orthopaedic complications of haemophilia. J Bone Joint Surg Br 80:191–196
Manco-Johnson MJ, Kempton CL, Reding MT, Lissitchkov T, Goranov S, Gercheva L et al (2013) Randomized, controlled, parallel-group trial of routine prophylaxis vs. on-demand treatment with sucrose-formulated recombinant factor VIII in adults with severe hemophilia A (SPINART). J Thromb Haemost 11:1119–1127
Sheth DS, Oldfield D, Ambrose C, Clyburn T (2004) Total knee arthroplasty in hemophilic arthropathy. J Arthroplasty 19:56–60
Rodríguez-Merchán EC (2007) Total knee replacement in haemophilic arthropathy. J Bone Joint Surg Br 89:186–188
Rodríguez-Merchán EC (2014) Review article: open versus arthroscopic synovectomy for pigmented villonodular synovitis of the knee. J Orthop Surg (Hong Kong) 22:406–408
Gu HF, Zhang SJ, Zhao C, Chen Y, Bi Q (2014) A comparison of open and arthroscopic surgery for treatment of diffuse pigmented villonodular synovitis of the knee. Knee Surg Sports Traumatol Arthrosc 22:2830–2836
Aurégan JC, Klouche S, Bohu Y, Lefèvre N, Herman S, Hardy P (2014) Treatment of pigmented villonodular synovitis of the knee. Arthroscopy 30:1327–1341
Zhang W, Likhodii S, Zhang Y, Aref-Eshghi E, Harper PE, Randell E et al (2014) Classification of osteoarthritis phenotypes by metabolomics analysis. BMJ Open 4(11):e006286
Lorenzo P, Bayliss MT, Heinegård D (2004) Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. Matrix Biol 23:381–391
Pan X, Huang L, Chen J, Dai Y, Chen X (2012) Analysis of synovial fluid in knee joint of osteoarthritis: 5 proteome patterns of joint inflammation based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Int Orthop 36:57–64
Hinman RS, Crossley KM (2007) Patellofemoral joint osteoarthritis: an important subgroup of knee osteoarthritis. Rheumatology (Oxford) 46:1057–1062
McAlindon TE, Snow S, Cooper C, Dieppe PA (1992) Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. Ann Rheum Dis 51:844–849
Wise BL, Niu J, Yang M, Lane NE, Harvey W, Felson DT, Hietpas J et al (2012) Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans. Arthritis Care Res (Hoboken) 64:847–852
Bartlett SJ, Ling SM, Mayo NE, Scott SC, Bingham CO 3rd (2011) Identifying common trajectories of joint space narrowing over two years in knee osteoarthritis. Arthritis Care Res (Hoboken) 63:1722–1728
Buck RJ, Wyman BT, Le Graverand MP, Hudelmaier M, Wirth W, Eckstein F et al (2010) Osteoarthritis may not be a one-way-road of cartilage loss–comparison of spatial patterns of cartilage change between osteoarthritic and healthy knees. Osteoarthritis Cartilage 18:329–335
Eckstein F, Wirth W, Hudelmaier M, Stein V, Lengfelder V, Cahue S et al (2008) Patterns of femorotibial cartilage loss in knees with neutral, varus, and valgus alignment. Arthritis Rheum 59:1563–1570
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Rodríguez-Merchán, E.C., Oussedik, S. (2015). The Arthritic Knee: Etiology and Patterns of Disease. In: Rodríguez-Merchán, E., Oussedik, S. (eds) Total Knee Arthroplasty. Springer, Cham. https://doi.org/10.1007/978-3-319-17554-6_2
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DOI: https://doi.org/10.1007/978-3-319-17554-6_2
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