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Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives

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Cardiac Fibrosis and Heart Failure: Cause or Effect?

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 13))

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Abstract

Scientists and surgeons can each benefit from a clear understanding of cardiac ECM and its’ influence on cardiac structure and function in both health and disease. This chapter highlights key concepts with respect to the influence of cardiac ECM in traditional surgical repairs and introduces emerging “biosurgical” strategies designed to leverage ECM biology and further enhance innovative surgical repairs to optimize cardiac performance.

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Authors and Affiliations

  1. Section of Cardiac Surgery, Department of Cardiac Sciences, Foothills Medical Centre, C880G, 1403-29th Street NW, T2N 2T9, Calgary, AB, Canada

    Holly E. M. Mewhort & Dr. Paul W. M. Fedak

Authors
  1. Holly E. M. Mewhort
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  2. Dr. Paul W. M. Fedak
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Correspondence to Paul W. M. Fedak .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface Hospital Research Centre Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada

    Ian M.C. Dixon

  2. Institute of Cardiovascular Sciences St. Boniface Hospital Research Centre Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada

    Jeffrey T. Wigle

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Mewhort, H., Fedak, P. (2015). Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives. In: Dixon, I., Wigle, J. (eds) Cardiac Fibrosis and Heart Failure: Cause or Effect?. Advances in Biochemistry in Health and Disease, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-319-17437-2_17

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