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Immunohistochemical Approach to the Diagnosis and Prognostic Evaluation of Pancreatic Neuroendocrine Neoplasms

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Book cover Pancreatic Neuroendocrine Neoplasms

Abstract

Pancreatic endocrine tumors include a broad spectrum of neoplasms. Immunohistochemical characterization of the tumors along with clinical evaluation is used to separate tumors into functioning and nonfunctioning neoplasms. Immunohistochemical detection of specific transcription factors can be helpful in the diagnosis and in the differential diagnosis of metastatic pancreatic endocrine tumors. Immunostaining for Ki-67 along with mitotic indices are the commonly used methods for grading pancreatic neuroendocrine tumors. In addition to the hormones normally detected in the pancreatic islets, a small percentage of pancreatic endocrine tumors produce ectopic hormones. Most pancreatic endocrine tumors that produce ectopic hormones are malignant tumors, but the molecular mechanisms of ectopic hormone production are not known. Immunohistochemical methods have become the cornerstone for diagnosis and for prognostic evaluation of pancreatic endocrine tumors.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA

    Ricardo V. Lloyd MD, PhD & Jason N. Rosenbaum MD

  2. Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN, 55905, USA

    Lori A. Erickson MD

Authors
  1. Ricardo V. Lloyd MD, PhD
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  2. Jason N. Rosenbaum MD
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  3. Lori A. Erickson MD
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Corresponding author

Correspondence to Ricardo V. Lloyd MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Pathology, Ospedale di Circolo, Varese, Italy

    Stefano La Rosa

  2. Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy

    Fausto Sessa

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Lloyd, R.V., Rosenbaum, J.N., Erickson, L.A. (2015). Immunohistochemical Approach to the Diagnosis and Prognostic Evaluation of Pancreatic Neuroendocrine Neoplasms. In: La Rosa, S., Sessa, F. (eds) Pancreatic Neuroendocrine Neoplasms. Springer, Cham. https://doi.org/10.1007/978-3-319-17235-4_7

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  • DOI: https://doi.org/10.1007/978-3-319-17235-4_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17234-7

  • Online ISBN: 978-3-319-17235-4

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