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Movement Disorder Genetics pp 19–34Cite as

Genetics of Parkinson’s Disease

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Abstract

Tremendous progress has been made over the last 10 years in the identification of genetic risk factors for Parkinson’s disease (PD). This work began with candidate gene-based assessments, where variability in the genes encoding alpha-synuclein, glucocerebrosidase, and leucine-rich repeat kinase 2 was assessed and shown to be linked to risk for disease. This work has been considerably extended upon using genome-wide association studies, which have thus far identified a large number of risk loci. Here we discuss these advances, the current picture of genetic risk factors in PD, and the path forward.

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Authors and Affiliations

  1. Laboratory of Neurogenetics, Genomic Technologies Group, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA

    Dena G. Hernandez PhD

  2. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA

    Andrew B. Singleton PhD

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Correspondence to Andrew B. Singleton PhD .

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  1. Department of Neurology, University Hospital Kiel, Kiel, Germany

    Susanne A. Schneider

  2. Department of Molecular Neuroscience, University College London, Institute of Neurology, London, United Kingdom

    José M. Tomás Brás

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Hernandez, D.G., Singleton, A.B. (2015). Genetics of Parkinson’s Disease. In: Schneider, S., Brás, J. (eds) Movement Disorder Genetics. Springer, Cham. https://doi.org/10.1007/978-3-319-17223-1_2

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