Abstract
There is converging evidence that clinical mild temperature hyperthermia sensitizes tumors to conventional therapies as chemotherapy and radiation therapy. Coupled with an increasing understanding of the biological basis of this synergy there has been a parallel increase in the ability to achieve, maintain, measure and monitor temperature and its physiological and physical consequences. A new entrant in the arena of hyperthermia generation is nanotechnology which capitalizes on locally injected or systemically administered nanoparticles that home to tumors and are activated by extrinsic energy sources to generate heat. This chapter highlights the unique opportunities and challenges with implementing hyperthermia mediated by a variety of engineered nanoparticles for cancer therapy.
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Abbreviations
- AMF:
-
Alternating magnetic field
- AuNRs:
-
Gold nanorods
- AuNSs:
-
Gold-silica nanoshells
- CTAB:
-
Cetylmethylamunium bromide
- EGFR:
-
Epidermal growth factor receptor
- EPR:
-
Enhanced permeability and retention
- HAuNS:
-
Hollow gold nanoshells
- MSH:
-
Melanocyte-stimulating hormone
- MWCNTs:
-
Multi walled carbon nanotubes
- NIR:
-
Near-infrared
- PEG:
-
Polyethylene glycol
- SAR:
-
Specific absorption rate
- SPIONs:
-
Superparamagnetic iron oxide nanoparticles
- SWCNTs:
-
Single walled carbon nanotubes
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Acknowledgements
This work was funded in part by grants from the National Institutes of Health (1R01CA155446, and U01CA151886), Department of Defense (PC111832), MD Anderson Institutional Research Grant, and the John E. and Dorothy J. Harris Endowed Professorship to SK.
Conflict of Interest The authors report no conflicts of interest.
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Quini, C.C., Krishnan, S. (2015). Potential Applications of Nanoparticles for Hyperthermia. In: Asea, A., Almasoud, N., Krishnan, S., Kaur, P. (eds) Heat Shock Protein-Based Therapies. Heat Shock Proteins, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-17211-8_11
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DOI: https://doi.org/10.1007/978-3-319-17211-8_11
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