Abstract
Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community.
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Acknowledgments
This work was supported by NIH grants (R01EY16501; P30CA34196), Foundation Fighting Blindness, VA Medical Research Service, and Research to Prevent Blindness.
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Charette, J. et al. (2016). A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects. In: Bowes Rickman, C., LaVail, M., Anderson, R., Grimm, C., Hollyfield, J., Ash, J. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 854. Springer, Cham. https://doi.org/10.1007/978-3-319-17121-0_24
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DOI: https://doi.org/10.1007/978-3-319-17121-0_24
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