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Soy and Psychotropic Effects: A Brief Overview

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Psychiatry and Neuroscience Update

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Abstract

Isoflavones first came to the attention of the scientific community in the 1940s because of fertility problems observed in sheep grazing on a type of isoflavone-rich clover. It was not until the 1990s, largely because of research sponsored by the U.S. National Cancer Institute, that the role of soy foods in disease prevention began to receive widespread attention. Subsequently, isoflavones and soy foods were being studied for their ability to alleviate hot flashes and inhibit bone loss in postmenopausal women. In 1995, soy protein attracted worldwide attention for its ability to lower cholesterol. At that same time, isoflavones began to be widely discussed as potential alternatives to conventional hormone therapy. There are other aspects about soy isoflavones to investigate that have been less studied. These are the psychotropic effects on anxiety, depression, and cognitive symptoms in menopausal women. The few studies that were found regarding the antidepressant effects of soy concluded that the administration of soybean could act as an alternative to estrogens in the treatment of depressive disorders during menopause. There were very few studies about soy in menopausal anxiety symptoms and cognitive symptoms. More studies are necessary in human beings with the goal of elucidating the role of soy in cognition in menopausal women. This chapter is a brief overview based on evidence from the past decade about the use of soy isoflavones in the treatment of the menopausal psychological symptoms.

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References

  1. Williams JK, Young DK, Adams MR, Chen M-F, Myers AK, Ramwell PW. Effects of estrogen on cardiovascular responses of premenopausal monkeys. J Pharmacol Exp Ther. 1994;1(2):671–6.

    Google Scholar 

  2. Messina M. A brief historical overview of the past two decades of soy and isoflavone research. J Nutr. 2010;140(7):1350S–4.

    Article  CAS  PubMed  Google Scholar 

  3. Richard-Davis G, Wellons M. Racial and ethnic differences in the physiology and clinical symptoms of menopause. Semin Reprod Med. 2013;31(5):380–6.

    Article  PubMed  Google Scholar 

  4. Mahn K, Borrás C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP, Sharpe RM, Viña J, Aaronson PI, Mann GE. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J. 2005;12:1755–7.

    Google Scholar 

  5. Rivas M, Garay RP, Escanero JF, Cia Jr P, Cia P, Alda JO. Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension. J Nutr. 2002;132(7):1900–2.

    CAS  PubMed  Google Scholar 

  6. Treudler R, Simon JC. Severe soy allergy in adults. Is there a role for specific immunotherapy? Hautarzt. 2012;63(4):307–12. doi:10.1007/s00105-011-2267-xGerman.

    Article  CAS  PubMed  Google Scholar 

  7. Melby MK. Climacteric symptoms among Japanese women and men: comparison of four symptom checklists. Climacteric. 2006;9(4):298–304.

    Article  CAS  PubMed  Google Scholar 

  8. Weeks J. On the outside moving in: will the alternative medicine integration movement shape U.S. healthcare? Healthc Forum J. 1998;41(6):14–9.

    CAS  PubMed  Google Scholar 

  9. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med. 2002;137(10):805–13.

    Article  PubMed  Google Scholar 

  10. Ahmad A, Biersack B, Li Y, Bao B, Kong D, Ali S, Banerjee S, Sarkar FH. Perspectives on the role of isoflavones in prostate cancer. AAPS J. 2013;15(4):991–1000. doi:10.1208/s12248-013-9507-1.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Kerckhoffs DAJM, Brouns F, Hornstra G, Mensink RP. Effects on the human serum lipoprotein profile of β-Glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols. J Nutr. 2002;132(9):2494–505.

    CAS  PubMed  Google Scholar 

  12. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 1995;333(5):276–82.

    Article  CAS  PubMed  Google Scholar 

  13. Food labeling: health claims; soy protein and coronary heart disease. Food and Drug Administration, HHS. Final rule. Fed Regist. 1999;64(206):57700–33.

  14. Kendall DA, Stancel GM, Enna SJ. Imipramine: effect of ovarian steroids on modifications in serotonin receptor binding. Science. 1981;211(4487):1183–5.

    Article  CAS  PubMed  Google Scholar 

  15. Avis NE, Brockwell S, Colvin A. A universal menopausal syndrome? Am J Med. 2005;118(Suppl 12B):37–46.

    Article  PubMed  Google Scholar 

  16. Huntley AL, Ernst E. Soy for the treatment of perimenopausal symptoms–a systematic review. Maturitas. 2004;47(1):1–9.

    Article  PubMed  Google Scholar 

  17. Obermeyer CM. Menopause across cultures: a review of the evidence. Menopause. 2000;7(3):184–92.

    Article  CAS  PubMed  Google Scholar 

  18. Avis NE, Stellato R, Crawford S, Bromberger J, Ganz P, Cain V, Kagawa-Singer M. Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med. 2001;52(3):345–56.

    Article  CAS  PubMed  Google Scholar 

  19. Im EO, Lee B, Chee W, Brown A, Dormire S. Menopausal symptoms among four major ethnic groups in the United States. West J Nurs Res. 2010;32(4):540–65. doi:10.1177/0193945909354343.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Récamier-Carballo S, Estrada-Camarena E, Reyes R, Fernández-Guasti A. Synergistic effect of estradiol and fluoxetine in young adult and middle-aged female rats in two models of experimental depression. Behav Brain Res. 2012;233(2):351–8. doi:10.1016/j.bbr.2012.05.034.

    Article  PubMed  Google Scholar 

  21. Geller SE, Studee L. Botanical and dietary supplements for menopausal symptoms: what works, what doesn’t. J Womens Health (Larchmt). 2005;14(7):634–49.

    Article  Google Scholar 

  22. Friedman-Koss D, Crespo CJ, Bellantoni MF, Andersen RE. The relationship of race/ethnicity and social class to hormone replacement therapy: results from the Third National Health and Nutrition Examination Survey 1988–1994. Menopause. 2002;9(4):264–72.

    Article  PubMed  Google Scholar 

  23. Crespo CJ, Smit E, Snelling A, Sempos CT, Andersen RE, NHANES III. Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and nondiabetic postmenopausal women: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2002;25(10):1675–80.

    Article  CAS  PubMed  Google Scholar 

  24. Haas JS, Kaplan CP, Gerstenberger EP, Kerlikowske K. Changes in the use of postmenopausal hormone therapy after the publication of clinical trial results. Ann Intern Med. 2004;140(3):184–8.

    Article  PubMed  Google Scholar 

  25. Hirata JD, Swiersz LM, Zell B, Small R, Ettinger B. Does dong quai have estrogenic effects in postmenopausal women? A doubleblind, placebo-controlled trial. Fertil Steril. 1997;68(6):981–6.

    Article  CAS  PubMed  Google Scholar 

  26. Wang SW, Chen Y, Joseph T, Hu M. Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein. J Altern Complement Med. 2008;14(3):287–97. doi:10.1089/acm.2007.0617.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Liang YL, Teede H, Dalais F, McGrath BP. The effects of phytoestrogen on blood pressure and lipids in healthy volunteers. Zhonghua Xin Xue Guan Bing Za Zhi. 2006;34(8):726–9.

    CAS  PubMed  Google Scholar 

  28. Goldstein MS, Glik D. Use of and satisfaction with homeopathy in a patient population. Altern Ther Health Med. 1998;4(2):60–5.

    CAS  PubMed  Google Scholar 

  29. Kass-Annese B. Alternative therapies for menopause. Clin Obstet Gynaecol. 2000;43(1):162–83.

    Article  CAS  Google Scholar 

  30. Szymanski LM, Lucidi RS. Estrogen therapy. Medscape [Internet; cited 2013 Oct 22]. Available from: http://emedicine.medscape.com/article/276107-overview

  31. Tham DM, Gardner CD, Haskell WL. Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab. 1998;83(7):2223–35.

    CAS  PubMed  Google Scholar 

  32. Ness J, Aronow WS, Beck G. Menopausal symptoms after cessation of hormone replacement therapy. Maturitas. 2006;53(3):356–61.

    Article  CAS  PubMed  Google Scholar 

  33. Etgen AM, Ungar S, Petitti N. Estradiol and progesterone modulation of norepinephrine neurotransmission: implications for the regulation of female reproductive behavior. J Neuroendocrinol. 1992;4(3):255–71. doi:10.1111/j.1365-2826.1992.tb00167.x.

    Article  CAS  PubMed  Google Scholar 

  34. Nina-Estrella RE, Landa AI, LaFuente JV, Gargiulo PA. Effects of antidepressants and soybean association in depressive menopausal women. Acta Pol Pharm. 2014;71(2):323–7.

    Google Scholar 

  35. Messina M, McCaskill-Stevens W, Lampe JW. Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. J Natl Cancer Inst. 2006;98(18):1275–84.

    Article  PubMed  Google Scholar 

  36. Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, Nicolaidis C, Walker M, Humphrey L. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA. 2006;295(17):2057–71.

    Article  CAS  PubMed  Google Scholar 

  37. Blake C, Fabick KM, Setchell KD, Lund TD, Lephart ED. Neuromodulation by soy diets or equol: anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects. BMC Neurosci. 2011;12:28. doi:10.1186/1471-2202-12-28.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  38. Landa AI, Gargiulo AJ, Gargiulo MM, Cabrera RJ, Bregonzio C, Lafuente Sánchez JV, Gargiulo PA. Alpha and beta noradrenergic mediation of NMDA glutamatergic effects on lordosis behaviour and plasmatic LH concentrations in the primed female rat. J Neural Transm. 2009;116(5):551–7.

    Article  CAS  PubMed  Google Scholar 

  39. Biegon A, Reches A, Snyder L, McEwen BS. Serotonergic and noradrenergic receptors in the rat brain: modulation by chronic exposure to ovarian hormones. Life Sci. 1983;32(17):2015–21.

    Article  CAS  PubMed  Google Scholar 

  40. Randolph Jr JF, Sowers M, Bondarenko IV, Harlow SD, Luborsky JL, Little RJ. Change in estradiol and follicle-stimulating hormone across the early menopausal transition: effects of ethnicity and age. J Clin Endocrinol Metab. 2004;89(4):1555–61.

    Article  CAS  PubMed  Google Scholar 

  41. de Sousa-Muñoz RL, Filizola RG. Efficacy of soy isoflavones for depressive symptoms of the climacteric syndrome. Maturitas. 2009;63(1):89–93. doi:10.1016/j.maturitas.2009.02.008.

    Article  PubMed  Google Scholar 

  42. Albertazzi P. A review of non-hormonal options for the relief of menopausal symptoms. Treat Endocrinol. 2006;5(2):101–13.

    Article  CAS  PubMed  Google Scholar 

  43. Melby MK, Lock M, Kaufert P. Culture and symptom reporting at menopause. Hum Reprod Update. 2005;11(5):495–512.

    Article  PubMed  Google Scholar 

  44. Mucci M, Carraro C, Mancino P, Monti M, Papadia LS, Volpini G, Benvenuti C. Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause. Minerva Ginecol. 2006;58(4):323–34.

    CAS  PubMed  Google Scholar 

  45. Ishiwata N, Melby MK, Mizuno S, Watanabe S. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women. Menopause. 2009;16(1):141–8. doi:10.1097/gme.0b013e31818379fa.

    Article  PubMed  Google Scholar 

  46. Li HF, Wang LD, Qu SY. Phytoestrogen genistein decreases contractile response of aortic artery in vitro and arterial blood pressure in vivo. Acta Pharmacol Sin. 2004;25(3):313–8.

    CAS  PubMed  Google Scholar 

  47. Chanawirat A, Khemapech S, Patumraj S, Siriviriyakul P. Genistein replacement therapy on endothelial dysfunction and bone loss in bilateral ovariectomized rats. Clin Hemorheol Microcirc. 2006;34(1–2):309–14.

    CAS  PubMed  Google Scholar 

  48. Casini ML, Marelli G, Papaleo E, Ferrari A, D’Ambrosio F, Unfer V. Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo-controlled study. Fertil Steril. 2006;85(4):972–8.

    Article  CAS  PubMed  Google Scholar 

  49. Clarkson TB, Anthony MS, Williams JK, Honore EK, Cline JM. The potential of soybean phytoestrogens for postmenopausal hormone replacement therapy. Proc Soc Exp Biol Med. 1998;217(3):365–8.

    Article  CAS  PubMed  Google Scholar 

  50. Wyss JM, Kadish I, van Groen T. Age-related decline in spatial learning and memory: attenuation by captopril. Clin Exp Hypertens. 2003;25(7):455–74.

    Article  CAS  PubMed  Google Scholar 

  51. Carlson S, Peng N, Prasain JK, Wyss JM. Effects of botanical dietary supplements on cardiovascular, cognitive, Effects of and metabolic function in males and females. Gend Med. 2008; 5 Suppl A:S76–90. doi: 10.1016/j.genm.2008.03.008.

  52. Zhao L, Mao Z, Chen S, Schneider LS, Brinton RD. Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer’s disease. J Alzheimers Dis. 2013;37(2):403–19.

    PubMed Central  CAS  PubMed  Google Scholar 

  53. Clement YN, Onakpoya I, Hung SK, Ernst E. Effects of herbal and dietary supplements on cognition in menopause: a systematic review. Maturitas. 2011;68(3):256–63.

    Article  PubMed  Google Scholar 

  54. Fournier LR, Ryan Borchers TA, Robison LM, Wiediger M, Park JS, Chew BP, McGuire MK, Sclar DA, Skaer TL, Beerman KA. The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women. J Nutr Health Aging. 2007;11(2):155–64.

    CAS  PubMed  Google Scholar 

  55. Society NAM. The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause. 2011;18(7):732–53. doi:10.1097/gme.0b013e31821fc8e0.

    Article  Google Scholar 

  56. de Souza Dos Santos MC, Gonçalves CF, Vaisman M, Ferreira AC, de Crvalho DP. Impact of flavonoids on thyroid function. Food Chem Toxicol. 2011;49(10):2495–502. doi:10.1016/j.fct.2011.06.074.

    Article  PubMed  Google Scholar 

  57. Mahmoud AM, Yang W, Bosland MC. Soy isoflavones and prostate cancer: a review of molecular mechanisms. J Steroid Biochem Mol Biol. 2014;140:116–32. doi:10.1016/j.jsbmb.2013.12.010.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Health Sciences, Department of Pharmacology, School of Physiological Sciences, University Autónoma of Santo Domingo, Santo Domingo, Dominican Republic

    Rose E. Nina Estrella M.D., Ph.D.

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  1. Rose E. Nina Estrella M.D., Ph.D.
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Correspondence to Rose E. Nina Estrella M.D., Ph.D. .

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Editors and Affiliations

  1. Guaymallen Mendoza, Argentina

    Pascual Ángel Gargiulo

  2. Member of the Council of the Institute of Neurobiology (Buenos Aires); Member of the Board of Certification, National Academy of Medicine (Argentina), Psychiatrist by University Complutense of Madrid and University of Buenos Aires; Former Director of National Institute of Mental Health (Argentina), Cuyo, Buenos Aires, Argentina

    Humberto Luis Mesones Arroyo

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Nina Estrella, R.E. (2015). Soy and Psychotropic Effects: A Brief Overview. In: Gargiulo, P., Arroyo, H. (eds) Psychiatry and Neuroscience Update. Springer, Cham. https://doi.org/10.1007/978-3-319-17103-6_14

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  • DOI: https://doi.org/10.1007/978-3-319-17103-6_14

  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-17103-6

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