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Abstract

Safety during organ recruitment means donor safety and organ safety. Efforts to advance transplant safety are ongoing and include improvements to screening tests and checks to detect any kind of donor disease and ensure good graft function after transplantation.

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References

  1. Nickkholgh A, Frey E, Krenzel C, Lauchart W, Flechtenmacher C, Schmidt J, Schemmer P. The need for vigilance in extended criteria donors with a past of malignancy: a case report and review of literature. Ann Tansplant. 2011;16:75–9.

    Google Scholar 

  2. Grossi PA, Fishman JA, AST Infectious Disease Community of Practice. Donor-derived infections in solid organ transplant recipients. Am J Transplant. 2009;9(Supp 4):S19–26.

    Article  PubMed  Google Scholar 

  3. Fishman JA, Greenwald MA, Grossi PA. Transmission of infection with human allograft: essential considerations in donor screening. Immunocompromised Hosts. 2012;55:720–7.

    Google Scholar 

  4. Fishman JA, Grossi PA. Donor-derived infection-the challenge for transplant safety. Nat Rev Nephrol. 2014;10:663–72.

    Article  PubMed  Google Scholar 

  5. Guide to the quality and safety of organs for transplantation. European Committee – partial agreement- on organ transplantation. 5th ed. 2013.

    Google Scholar 

  6. Kauffman HM, McBride MA, Cherikh WS, Spain PC, Marks WH, Roza AM. Transplant tumor registry: donor related malignancies. Transplantation. 2002;4:358.

    Article  Google Scholar 

  7. Desai R, Collett D, Watson CJ, Johnson P, Evans T, Neuberger J. Cancer transmission from organ donors – unavoidable but low risk. Transplantation. 2012;94:1200–7.

    Article  PubMed  Google Scholar 

  8. Nalesnik MA, Woodle ES, Dimaio JM, Vasudev B, Teperman LW, Covington S, Taranto S, Gockerman JP, Shapiro R, Sharma V, Swinnen LJ, Yoshida A, Ison MG. Donor-transmitted malignancies in organ transplantation: assessment of clinical risk. Am J Transplant. 2011;11(6):1140–7.

    Article  CAS  PubMed  Google Scholar 

  9. Detry O, Bonnet P, Honorè P, Meurisse M, Jacquet N. What is the risk of transferral of an undetected neoplasm during organ transplantation? Tranplant Proc. 1997;29:2410–1.

    Article  CAS  Google Scholar 

  10. Buell JF, Hanaway MJ, Thomas M, Munda R, Alloway RR, First MR, Woodle ES. Donor kidneys with small renal cell cancers: can they be transplanted? Transplant Proc. 2005;37(2):581–2.

    Article  CAS  PubMed  Google Scholar 

  11. Sack FU, Lange R, Mehmanesh H, Amman K, Schnabel P, Zimmermann R, Dengler T, Otto HF, Hagl S. Transferral of extrathoracic donor neoplasm by the cardiac allograft. J Heart Lung Transplant. 1997;16(3):298–301.

    CAS  PubMed  Google Scholar 

  12. Ferreira GF, Azevedo de Oliveira R, Jorge LB, Nahas WC, Saldanha LB, Ianhez LE, Srougi M. Urothelial carcinoma transmission via kidney transplantation. Nephrol Dial Transplant. 2010;25:641–3.

    Article  PubMed  Google Scholar 

  13. Barrou B, Bitker MO, Delcourt A, Ourahma S, Richard F. Fate of renal tubulopapillary adenoma transmitted by an organ donor. Transplantation. 2001;72(3):540–1.

    Article  CAS  PubMed  Google Scholar 

  14. Llamas F, Gallego E, Salinas A, Virseda J, Pérez J, Ortega A, Nam SH, Gómez C. Sarcomatoid renal cell carcinoma in a renal transplant recipient. Transplant Proc. 2009;41(10):4422–4.

    Article  CAS  PubMed  Google Scholar 

  15. D'Errico-Grigioni A, Fiorentino M, Vasuri F, Corti B, Ridolfi L, Grigioni WF, Pathology Unit for organ safety of the F. Addarii Institute, Bologna, Bagni A, Pirini MG, Malvi D, Fabbrizio B, Caprara G, Alvaro N. Expanding the criteria of organ procurement from donors with prostate cancer: the application of the new Italian guidelines. Am J Transplant. 2010;10(8):1907–11.

    Article  PubMed  Google Scholar 

  16. Forbes GB, Goggin MJ, Dische FE, Saeed IT, Parsons V, Harding MJ, Bewick M, Rudge CT. Accidental transplantation of bronchial carcinoma from a cadaver donor to two recipients of renal allografts. J Clin Pathol. 1981;34(2):109–15.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Winter TC, Keller PR, Lee Jr FT, Pozniak MA. Donor-derived malignancy: transmission of small-cell lung cancer via renal transplantation. J Ultrasound Med. 2001;20(5):559–62.

    CAS  PubMed  Google Scholar 

  18. Lipshutz GS, Baxter-Lowe LA, Nguyen T, Jones KD, Ascher NL, Feng S. Death from donor-transmitted malignancy despite emergency liver retransplantation. Liver Transpl. 2003;9(10):1102–7.

    Article  PubMed  Google Scholar 

  19. Zwald FO, Christenson LJ, Billingsley EM, Zeitouni NC, Ratner D, Bordeaux J, Patel MJ, Brown MD, Proby CM, Euvrard S, Otley CC, Stasko T, Melanoma Working Group of The International Transplant Skin Cancer Collaborative and Skin Care in Organ Transplant Patients, Europe. Melanoma in solid organ transplant recipients. Am J Transplant. 2010;10(5):1297–304.

    Article  CAS  PubMed  Google Scholar 

  20. Strauss DC, Thomas M. Transmission of donor melanoma by organ transplantation. Lancet Oncol. 2010;11:790–6.

    Article  PubMed  Google Scholar 

  21. MacKie RM, Reid R, Junor B. Fatal melanoma transferred in a donated kidney 16 years after melanoma surgery. N Engl J Med. 2003;348:567–8.

    Article  PubMed  Google Scholar 

  22. Bajai NS, Watt C, Hadjiliadis D, Gillespie C, Haas AR, Pochettino A, Mendez J, Sterman DH, Schuchter LM, Christie JD, Lee JC, Ahya VN. Donor transmission of malignant melanoma in a lung transplant recipient 32 years after curative resection. Transpl Int. 2010;23(7):e26–31.

    Article  Google Scholar 

  23. Gandhi MJ, Strong DM. Donor derived malignancy following transplantation: a review. Cell Tissue Bank. 2007;8:267–86.

    Article  PubMed  Google Scholar 

  24. Kauffman HM, McBride MA, Cherikh WS, Spain PC, Delmonico FL. Transplant tumor registry: donors with central nervous system tumors. Transplantation. 2002;73(4):579–82.

    Article  PubMed  Google Scholar 

  25. Kauffman HM, Cherikh WS, McBride MA, Cheng Y, Hanto DW. Deceased donors with a past history of malignancies: an organ procurement and transplantation network/united network for organ sharing update. Transplantation. 2007;84(2):272–4.

    Article  PubMed  Google Scholar 

  26. Warrens AN, Birch R, Collett D, Daraktchiev M, Dark JH, Galea G, Gronow K, Neuberger J, Hilton D, Whittle IR, Watson CJ, Advisory Committee on the Safety of Blood, Tissues and Organs, UK. Advising potential recipients on the use of organs from donors with primary central nervous system tumors. Transplantation. 2012;93(4):348–53.

    Article  PubMed  Google Scholar 

  27. Watson CJ, Roberts R, Wright KA, Greenberg DC, Rous BA, Brown CH, Counter C, Collett D, Bradley JA. How safe is it to transplant organs from deceased donors with primary intracranial malignancy? an analysis of UK registry data. Am J Transplant. 2010;10(6):1437–44.

    Article  CAS  PubMed  Google Scholar 

  28. Jonas S, Bechstein WO, Lemmens HP, Neuhaus R, Thalmann U, Neuhaus P. Liver graft-transmitted glioblastoma multiforme. A case report and experience with 13 multiorgan donors suffering from primary cerebral neoplasia. Transpl Int. 1996;9:426–9.

    Article  CAS  PubMed  Google Scholar 

  29. Frank S, Muller J, Bonk C, Haroske G, Schackert HK, Schackert G. Transmission of glioblastoma multiforme through liver transplantation. Lancet. 1998;352:31.

    Article  CAS  PubMed  Google Scholar 

  30. Watson CJE, Bradley JA. Evaluating the risk of cancer transmission to optimize organ usage. Am J Transplant. 2011;11:1113–4.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Antonia D’Errico .

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D’Errico, A., Malvi, D., Vasuri, F. (2015). The Safety of Donor. In: Pinna, A., Ercolani, G. (eds) Abdominal Solid Organ Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-16997-2_4

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  • DOI: https://doi.org/10.1007/978-3-319-16997-2_4

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16996-5

  • Online ISBN: 978-3-319-16997-2

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