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Screening the Single Euploid Embryo pp 203–215Cite as

Expanding PGD Applications to Nontraditional Genetic and Non-genetic Conditions

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Abstract

PGD is presently a safe, accurate, and reliable technique for embryo evaluation with growing value for prevention of genetic disorders. It has been applied for approximately 400 different genetic conditions, with over 99 % accuracy rate in leading PGD centers. Available experience provides the basis for a wider application of PGD not only for genetic diseases currently diagnosed by prenatal diagnosis but also for nontraditional indications for which prenatal diagnosis has not previously been practiced. This includes late-onset and complex disorders with genetic predisposition, such as inherited cancers, familial cardiac diseases, Alzheimer disease/dementia, as well as non-genetic conditions, involving preselection of HLA-matched embryos. This makes PGD a useful tool for improving the access to HLA-compatible stem cell transplantation for congenital and acquired disorders through PGD for HLA matching, already performed in over a thousand cases and resulting in successful HLA-compatible stem cell transplantation. The practical value of PGD is thus no longer limited to the prevention of monogenic disorders but expanded to the treatment of siblings requiring stem cell transplantation.

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Conflict of Interest

The authors declare no conflict.

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Authors and Affiliations

  1. Reproductive Genetics Institute, Chicago, IL, USA

    Anver Kuliev, Svetlana Rechitsky & Oleg Verlinsky

  2. Reproductive Genetic Innovations, 2910 MacArthur Boulevard, Northbrook, IL, 60062, USA

    Anver Kuliev

Authors
  1. Anver Kuliev
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  2. Svetlana Rechitsky
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  3. Oleg Verlinsky
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Corresponding author

Correspondence to Anver Kuliev .

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Editors and Affiliations

  1. Center for Advanced Genetics, Reproductive Research Section, Carlsbad, California, USA

    E Scott Sills

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© 2015 Springer International Publishing Switzerland

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Kuliev, A., Rechitsky, S., Verlinsky, O. (2015). Expanding PGD Applications to Nontraditional Genetic and Non-genetic Conditions. In: Sills, E. (eds) Screening the Single Euploid Embryo. Springer, Cham. https://doi.org/10.1007/978-3-319-16892-0_15

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  • DOI: https://doi.org/10.1007/978-3-319-16892-0_15

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16891-3

  • Online ISBN: 978-3-319-16892-0

  • eBook Packages: MedicineMedicine (R0)

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