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RNA Methylation in the Control of Stem Cell Activity and Epidermal Differentiation

  • Abdulrahim A. Sajini
  • Michaela FryeEmail author
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Abundant non-coding RNAs including transfer and ribosomal RNAs are extensively modified, and some of these chemical modifications such as methylation also occur in regulatory non-coding RNAs and coding RNAs. The deposition of a methyl mark onto adenosines (m6A) and cytosines (m5C) is highly conserved and both have emerged as important modifications regulating fundamental cellular processes in developing and adult tissues in mammals. In this chapter, we will review the broad roles of m6A and m5C post-transcriptional methylation in regulating stem cell fate and differentiation processes in skin and other adult tissues, and we will discuss the existence of an additional layer of protein expression control through epigenetic regulation at the RNA level.

Notes

Acknowledgments

The authors thank members of the Frye Laboratory for helpful discussion. M.F. is supported by grants from Cancer Research UK (CR-UK), the European Research Council (ERC), the Medical Research Council (MRC), and Worldwide Cancer Research (WCR). A.S. was funded by a scholarship from the University of Tabuk, Saudi Arabia.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.University of Cambridge, Department of GeneticsCambridgeUK
  2. 2.Department of Biomedical EngineeringKhalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates

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