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Long Noncoding RNA and Its Role in the Control of Gene Expression in the Skin

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Epigenetic Regulation of Skin Development and Regeneration

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Epithelial tissues in animals regulate life-sustaining processes at the boundary between the host and its environment. It is becoming evident that regulatory noncoding RNAs play fundamental roles in orchestrating the formation of the skin, including lineage-specific commitment and specialization, often operating at the interface between stemness and differentiation. In this review, we discuss the current understanding of how members of a specific class of RNAs, long noncoding RNAs (lncRNAs), function in the control of gene expression to regulate development and adult stem cell maintenance in the skin. Understanding the activities of lncRNAs will elucidate a novel mechanism that modulates gene expression in the skin, and could ultimately lead to targeted noncoding RNA-based therapies to improve effectiveness of current regenerative strategies and provide new avenues for repair.

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Authors and Affiliations

  1. Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA

    Kevin C. Wang & Howard Y. Chang

  2. Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA

    Kevin C. Wang

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  1. Kevin C. Wang
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  2. Howard Y. Chang
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Correspondence to Howard Y. Chang .

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Editors and Affiliations

  1. Centre for Skin Sciences, University of Bradford, Bradford, UK

    Vladimir A. Botchkarev

  2. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Sarah E. Millar

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Wang, K.C., Chang, H.Y. (2018). Long Noncoding RNA and Its Role in the Control of Gene Expression in the Skin. In: Botchkarev, V., Millar, S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-16769-5_8

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