Radiation Therapy for Glioma Stem Cells

  • Anthony E. Rizzo
  • Jennifer S. YuEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 853)


Radiation therapy is the most effective adjuvant treatment modality for virtually all patients with high-grade glioma. Its ability to improve patient survival has been recognized for decades. Cancer stem cells provide new insights into how tumor biology is affected by radiation and the role that this cell population can play in disease recurrence. Glioma stem cells possess a variety of intracellular mechanisms to resist and even flourish in spite of radiation, and their proliferation and maintenance appear tied to supportive stimuli from the tumor microenvironment. This chapter reviews the basis for our current use of radiation to treat high-grade gliomas, and addresses this model in the context of therapeutically resistant stem cells. We discuss the available evidence highlighting current clinical efforts to improve radiosensitivity, and newer targets worthy of further development.


Glioma Stem cell Initiating cell Glioblastoma Radiation Radioresistance Microenvironment Hypoxia DNA damage repair 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Stem Cell Biology and Regenerative Medicine, Lerner Research InstituteCleveland ClinicClevelandUSA
  2. 2.Department of Radiation OncologyCleveland ClinicClevelandUSA

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