Regulation of Subventricular Zone-Derived Cells Migration in the Adult Brain

Capilla-Gonzalez, Vivian; Lavell, Emily; Quiñones-Hinojosa, Alfredo; Guerrero-Cazares, Hugo

doi:10.1007/978-3-319-16537-0_1

Vivian Capilla-Gonzalez^2,3,
Emily Lavell³,
Alfredo Quiñones-Hinojosa³ &
…
Hugo Guerrero-Cazares M.D., Ph.D.⁴

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 853))

2214 Accesses
27 Citations

Abstract

The subventricular zone of the lateral ventricles (SVZ) is the largest source of neural stem cells (NSCs) in the adult mammalian brain. Newly generated neuroblasts from the SVZ form cellular chains that migrate through the rostral migratory stream (RMS) into the olfactory bulb (OB), where they become mature neurons. Migration through the RMS is a highly regulated process of intrinsic and extrinsic factors, orchestrated to achieve direction and integration of neuroblasts into OB circuitry. These factors include internal cytoskeletal and volume regulators, extracellular matrix proteins, and chemoattractant and chemorepellent proteins. All these molecules direct the cells away from the SVZ, through the RMS, and into the OB guaranteeing their correct integration. Following brain injury, some neuroblasts escape the RMS and migrate into the lesion site to participate in regeneration, a phenomenon that is also observed with brain tumors. This review focuses on factors that regulate the migration of SVZ precursor cells in the healthy and pathologic brain. A better understanding of the factors that control the movement of newly generated cells may be crucial for improving the use of NSC-replacement therapy for specific neurological diseases.

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Stem Cells Department, Andalusian Molecular Biology and Regenerative Medicine Centre, Seville, Spain
Vivian Capilla-Gonzalez
Department of Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Vivian Capilla-Gonzalez, Emily Lavell & Alfredo Quiñones-Hinojosa
Department of Neurosurgery, Johns Hopkins University, 1550 Orleans St, CRBII, Room 247B, Baltimore, MD, 21201, USA
Hugo Guerrero-Cazares M.D., Ph.D.

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Vivian Capilla-Gonzalez
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Emily Lavell
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Alfredo Quiñones-Hinojosa
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Hugo Guerrero-Cazares M.D., Ph.D.
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Correspondence to Hugo Guerrero-Cazares M.D., Ph.D. .

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Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Moneeb Ehtesham

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Capilla-Gonzalez, V., Lavell, E., Quiñones-Hinojosa, A., Guerrero-Cazares, H. (2015). Regulation of Subventricular Zone-Derived Cells Migration in the Adult Brain. In: Ehtesham, M. (eds) Stem Cell Biology in Neoplasms of the Central Nervous System. Advances in Experimental Medicine and Biology, vol 853. Springer, Cham. https://doi.org/10.1007/978-3-319-16537-0_1

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