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Assessing Cognitive Improvement in People with Down Syndrome: Important Considerations for Drug-Efficacy Trials

  • Chapter
Cognitive Enhancement

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 228))

Abstract

Experimental research over just the past decade has raised the possibility that learning deficits connected to Down syndrome (DS) might be effectively managed by medication. In the current chapter, we touch on some of the work that paved the way for these advances and discuss the challenges associated with translating them. In particular, we highlight sources of phenotypic variability in the DS population that are likely to impact performance assessments. Throughout, suggestions are made on how to detect meaningful changes in cognitive–adaptive function in people with DS during drug treatment. The importance of within-subjects evaluation is emphasized.

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Acknowledgements

We acknowledge Ms. Lucy Han for her assistance in preparing the manuscript. Special thanks are extended to the LuMind Foundation, the Anna and John J. Sie Foundation, and Research Down syndrome for their tireless support. This work was also funded under R01 HD38384 from the National Institute of Child Health and Human Development. F.F. is indebted to J.O. Edgin for her wellspring of enthusiasm, inspiration, and strength.

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Authors and Affiliations

  1. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Fabian Fernandez & Roger H. Reeves

  2. Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    Fabian Fernandez & Roger H. Reeves

Authors
  1. Fabian Fernandez
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  2. Roger H. Reeves
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Correspondence to Fabian Fernandez .

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Editors and Affiliations

  1. Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA

    Kathleen M. Kantak

  2. Roche Pharmaceutical Research and Early Development; Neuroscience, Ophthalmology and Rare Diseases, F. Hoffmann-La Roche Ltd., Basel, Switzerland

    Joseph G. Wettstein

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© 2015 Springer International Publishing Switzerland

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Fernandez, F., Reeves, R.H. (2015). Assessing Cognitive Improvement in People with Down Syndrome: Important Considerations for Drug-Efficacy Trials. In: Kantak, K., Wettstein, J. (eds) Cognitive Enhancement. Handbook of Experimental Pharmacology, vol 228. Springer, Cham. https://doi.org/10.1007/978-3-319-16522-6_12

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