Abstract
The objective of endodontic treatment is to treat and/or prevent apical periodontitis. Historically, there have been many irrigating agents that have been used to achieve this objective. Sodium hypochlorite, to date, still remains the irrigant of choice to break down the organic tissue of the dental pulp, debride necrotic tissue from the root canal space, and confirm negative bacteria cultures. Sodium hypochlorite while being an excellent endodontic irrigant can also cause devastating complications if extruded past the apex into the periradicular tissues.
This chapter will outline the complications and sequelae that potentially can occur if sodium hypochlorite is accidentally extruded past the apex and into the periradicular tissues. The mechanism of action of the irrigation accident will be detailed as well as preventative measures that can be employed to avoid such occurrences in addition to suggested treatment recommendations should such an accident occur. In addition, the legal and ethical implications with respect to the use and delivery of sodium hypochlorite during endodontic treatment will also be discussed.
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References
Black GV. Special dental pathology. Chicago: Medico-Dental Publishing Co; 1915. p. 295.
Prinz H. Diseases of the soft structures of the teeth and their treatment. Philadelphia: Lea & Febiger; 1928. p. 225.
Bender IB, Seltzer S, Turkenkopf S. To culture or not to culture? Oral Surg Oral Med Oral Pathol. 1964;18:527–40.
Seltzer S, Bender IB. Cognitive dissonance in endodontics. Oral Surg Oral Med Oral Pathol. 1965;20:505–16.
Spånberg LSW. Editorial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:577–8.
Ricucci D, Siqueira Jr JF. Biofilms and apical periodontitis: study of prevalence and association with clinical and histopathologic findings. J Endod. 2010;36(8):1277–88.
Nair PN, Henry S, Cano V, et al. Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after “one-visit” endodontic treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:231–52.
Clegg MS, Vertucci FJ, Walker C, Belanger M, Britto LR. The effect of exposure to irrigant solutions on apical dentin biofilms in vitro. J Endod. 2006;32(5):434–7.
Pashley EL, Birdsong NL, Bowman K, Pashley DH. Cytotoxic effects of NaOCl on vital tissue. J Endod. 1985;11(12):525–8.
Zhu WC, Gyamfi J, Niu LN, Schoeffel GJ, Liu SY, Santarcangelo F, Khan S, Tay KC, Pashley DH, Tay FR. Anatomy of sodium hypochlorite accidents involving facial ecchymosis – a review. J Dent. 2013;41(11):935–48.
Zairi A, Lambrianidis T. Accidental extrusion of sodium hypochlorite into the maxillary sinus. Quintessence Int. 2008;39(9):745–8.
Oreadi D, Hendi J, Papageorge MB. A clinico-pathologic correlation. J Mass Dent Soc. 2010;59(3):44–6.
Wang S, Chung M, Cheng J, Chen C, Shieh Y. Sodium hypochlorite accidentally extruded beyond the apical foramen. J Med Sci. 2010;30(2):61–5.
Bowden J, Ethunandan M, Brennan P. Life-threatening airway obstruction secondary to hypochlorite extrusion during root canal treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:402–4.
Markose G, Cotter CJ, Hislop WS. Facial atrophy following accidental subcutaneous extrusion of sodium hypochlorite. Br Dent J. 2009;206(5):263–4.
Pelka M, Petschelt A. Permanent mimic musculature and nerve damage caused by sodium hypochlorite: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(3):e80–3.
Bosch-Aranda ML, Vázquez-Delgado E, Gay-Escoda C. Atypical odontalgia: a systematic review following the evidence-based principles of dentistry. Cranio. 2011;29(3):219–26.
Peck BW, Workeneh B, Kadikoy H, Abdellatif A. Sodium hypochlorite-induced acute kidney injury. Saudi J Kidney Dis Transpl. 2014;25(2):381–4.
Kleier DJ, Averbach RE, Mehdipour O. The sodium hypochlorite accident: experience of diplomates of the American Board of Endodontics. J Endod. 2008;34(11):1346–50.
Salzgeber RM, Brilliant JD. An in vivo evaluation of the penetration of an irrigating solution in root canals. J Endod. 1977;3(10):394–8.
Gondim Jr E, Setzer F, dos-Carmo CD, Kim S. Postoperative pain after the application of two different irrigation devices in a prospective randomized clinical trial irrigation devices in a prospective randomized clinical trial. J Endod. 2010;36(8):1295–301.
Witton R, Brennan PA. Severe tissue damage and neurological deficit following extravasation of sodium hypochlorite solution during routine endodontic treatment. Br Dent J. 2005;198(12):749–50.
Boutsioukis C, Psimma Z, van der Sluis LW. Factors affecting irrigant extrusion during root canal irrigation: a systematic review. Int Endod J. 2013;46(7):599–618.
Psimma Z, Boutsioukis C, Vasiliadis L, Kastrinakis E. A new method for real-time quantification of irrigant extrusion during root canal irrigation ex vivo. Int Endod J. 2013;46(7):619–31.
Psimma Z, Boutsioukis C, Kastrinakis E, Vasiliadis L. Effect of needle insertion depth and root canal curvature on irrigant extrusion ex vivo. J Endod. 2013;39(4):521–4.
Boutsioukis C, Psimma Z, Kastrinakis E. The effect of flow rate and agitation technique on irrigant extrusion ex vivo. Int Endod J. 2014;47(5):487–96.
Mehra P, Clancy C, Wu J. Formation of a facial hematoma during endodontic therapy. J Am Dent Assoc. 2000;131(1):67–71.
Hülsmann M, Rödig T, Nordmeye S. Complications during root canal irrigation. Endod Topics 2009. 2007;16(1):27–63.
Desai P, Himel V. Comparative safety of various intracanal irrigation systems. J Endod. 2009;35(4):545–9.
Hauman CH, Chandler NP, Tong DC. Endodontic implications of the maxillary sinus: a review. Int Endod J. 2002;35(2):127–41.
Ehrich DG, Brian Jr JD, Walker WA. Sodium hypochlorite accident: inadvertent injection into the maxillary sinus. J Endod. 1993;19(4):180–2.
Kavanagh CP, Taylor J. Inadvertent injection of sodium hypochlorite into the maxillary sinus. Br Dent J. 1998;185(7):336–7.
Sleiman P. Irrigation for the root canal and nothing but the root canal. Roots. 2012;4:32–33.
Mehdipour O, Kleier DJ, Averbach RE. Anatomy of sodium hypochlorite accidents. Compend Contin Educ Dent. 2007;28(10):544–6.
Hülsmann M, Hahn W. Complications during root canal irrigation – literature review and case reports. Int Endod J. 2000;33(3):186–93.
de Sermeño RF, da Silva LA, Herrera H, Herrera H, Silva RA, Leonardo MR. Tissue damage after sodium hypochlorite extrusion during root canal treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(1):e46–9.
Rickles NH, Joshi BA. A possible case in a human and an investigation in dogs of death from air embolism during root canal therapy. J Am Dent Assoc. 1963;67:397–404.
Davies JM, Campbell LA. Fatal air embolism during dental implant surgery: a report of three cases. Can J Anaesth. 1990;37(1):112–21.
Manisali Y, Yücel T, Erişen R. Overfilling of the root. A case report. Oral Surg Oral Med Oral Pathol. 1989;68(6):773–5.
Drake R, Vogl AW, Mitchell AWM. Gray’s anatomy for students. 2nd ed. London: Churchill Livingstone/Elsevier; 2009. Chapter 8.
Schoeffel GJ. The dynamic response characteristics of the periodontal ligament at the apical foramen to increased intracanal gaseous pressure. Harvard University Master Thesis, Boston; 1980, A-5.
Drinker CK, Drinker KR, Lund CC. The circulation in the mammalian bone marrow. Am J Physiol. 1922;62:1–92.
Draenert K, Draenert Y. The vascular system of bone marrow. Scan Electron Microsc. 1980;4:113–22.
Oni OO, Stafford H, Gregg PJ. An investigation of the routes of venous drainage from the bone marrow of the human tibial diaphysis. Clin Orthop Relat Res. 1988;230:237–44.
de Saint-Georges L, Miller SC. The microcirculation of bone and marrow in the diaphysis of the rat hemopoietic long bones. Anat Rec. 1992;233:169–77.
Kofoed H. Intraosseous pressure, gas tension and bone blood flow in normal and pathological situations: a survey of methods and results. Bone Circulation and Vascularization in Normal and Pathological Conditions. NATO ASI Ser. 1993;247:101–11.
Gurkan UA, Akkus O. The mechanical environment of bone marrow: a review. Ann Biomed Eng. 2008;36:1978–91.
Helm M, Breschinski W, Lampl L, et al. Intraosseous puncture in preclinical emergency medicine. Experiences of an air rescue service. Anaesthesist. 1996;45(12):1196–202.
Josefson A. A new method of treatment – intraosseous injections. Acta Med Scand. 1934;81:550–64.
Arbeiter HI, Greengard J. Tibial bone marrow infusion in infants. J Pediatr. 1944;25:1–12.
Elston JT, Jayne RV, Kaump DH, et al. Intraosseous infusions in infants. Am J Clin Pathol. 1947;17:143–50.
Heinild S, Sondergaard T, Tudvad F. Bone marrow infusion in childhood: experiences from a thousand infusions. J Pediatr. 1947;30:400–12.
Tocantins LM. Rapid absorption of substances injected into the bone marrow. Proc Soc Exp Biol Med. 1940;45:292–6.
Tocantins LM, O’Neil JF. Infusions of blood and other fluids into the general circulation via the bone marrow. Surg Gynecol Obstet. 1941;73:281–7.
Tocantins LM, O’Neil JF, Jones HW. Infusions of blood and other fluids via the bone marrow. JAMA. 1941;117:1229–34.
Tocantins LM, O’Neil JF. Complications of intraosseous therapy. Ann Surg. 1945;122:266–77.
Brown R. Intraosseous anesthesia: a review. J Calif Dent Assoc. 1999;27:785–92.
Park E, Shen Y, Khakpour M, Haapasalo M. Apical pressure and extent of irrigant flow beyond the needle tip during positive-pressure irrigation in an in vitro root canal model. J Endod. 2013;39(4):511–5.
Khan S, Niu LN, Eid AA, Looney SW, Didato A, Roberts S, et al. Periapical pressures developed by nonbinding irrigation needles at various irrigation delivery rates. J Endod. 2013;39(4):529–33.
Boutsioukis C, Lambrianidis T, Kastrinakis E. Irrigant flow within a prepared root canal using various flow rates: a computational fluid dynamics study. Int Endod J. 2009;42(2):144–55.
Boutsioukis C, Gogos C, Verhaagen B, Versluis M, Kastrinakis E, Van der Sluis LW. The effect of apical preparation size on irrigant flow in root canals evaluated using an unsteady computational fluid dynamics model. Int Endod J. 2010;43(10):874–81.
Boutsioukis C, Gogos C, Verhaagen B, Versluis M, Kastrinakis E, Van der Sluis LW. The effect of root canal taper on the irrigant flow: evaluation using an unsteady computational fluid dynamics model. Int Endod J. 2010;43(10):909–16.
Boutsioukis C, Lambrianidis T, Verhaagen B, Versluis M, Kastrinakis E, Wesselink PR, van der Sluis LW. The effect of needle-insertion depth on the irrigant flow in the root canal: evaluation using an unsteady computational fluid dynamics model. J Endod. 2010;36(10):1664–8.
Boutsioukis C, Verhaagen B, Versluis M, Kastrinakis E, Wesselink PR, van der Sluis PR. Evaluation of irrigant flow in the root canal using different needle types by an unsteady computational fluid dynamics model. J Endod. 2010;36(5):875–97.
Hess W. The anatomy of the root-canals of the teeth of the permanent dentition. New York: Wood; 1925.
Boutsioukis C, Lambrianidis T, Kastrinakis E, Bekiaroglou P. Measurement of pressure and flow rates during irrigation of a root canal ex vivo with three endodontic needles. Int Endod J. 2007;40(7):504–13.
Tegginmani VS, Chawla VL, Kahate MM, Jain VS. Hypochlorite accident – a case report. Endodontology (Indian Endod Soc). 2011;23:89–94.
Bradford CE, Eleazer PD, Downs KE, Scheetz JP. Apical pressures developed by needles for canal irrigation. J Endod. 2002;28(4):333–5.
Spencer HR, Ike V, Brennan PA. Review: the use of sodium hypochlorite in endodontics—potential complications and their management. Br Dent J. 2007;202(9):555–9.
Hales JJ, Jackson CR, Everett AP, Moore SH. Treatment protocol for the management of a sodium hypochlorite accident during endodontic therapy. Gen Dent. 2001;49:278–81.
Ingle JI. Endodontics. Philadelphia: Lea & Febiger; 1965. p. 175–6.
Becket GL, Cohen S, Borer R. The sequelae of accidentally injecting sodium hypochlorite beyond the root apex. Oral Surg. 1974;38:633–8.
Meisel A, Kuczewski M. Legal and ethical myths about informed consent. Arch Intern Med. 1996;156(22):2521–6.
Edwin AK. Don’t lie but don’t tell the whole truth: the therapeutic privilege is it ever justified? Ghana Med J. 2008;42(4):156–61.
http://uwtortswikimiller.wikifoundry.com/page/California [Note to reader: Opening this website will open on California, but the other states are listed on the left].
Cohenca N. Disinfection of root canal systems: the treatment of apical periodontitis. Ames: Wiley; 2014. p. 163.
Goode N, Khan S, Eid AA, Niu LN, Gosier J, Susin LF, Pashley DH, Tay FR. Wall shear stress effects of different endodontic irrigation techniques and systems. J Dent. 2013;41(7):636–41.
Nielsen BA, Craig Baumgartner J. Comparison of the EndoVac system to needle irrigation of root canals. J Endod. 2007;33:611–5.
Ribeiro EM, Silva-Sousa YTC, Souza-Gabriel AE, Sousa-Neto MD, Lorencetti KT, Silva SRC. Debris and smear removal in flattened root canals after use of different irrigant agitation protocols. Microsc Res Tech. 2012;75:781–90.
Shin S-J, Kim H-K, Jung I-Y, Lee C-Y, Lee S-J, Kim E. Comparison of the cleaning efficacy of a new apical negative pressure irrigating system with conventional irrigation needles in the root canals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:479–84.
Malentacca A, Uccioli U, Zangari D, Lajolo C, Fabiani C. Efficacy and safety of various active irrigation devices when used with either positive or negative pressure: an in vitro study. J Endod. 2012;38:1622–6.
Note and Acknowledgement
Figure 11: The pressures recorded for the macro cannula were not reported in the Khan study [59] but were mentioned in Goode [79] as unpublished results. Goode coauthored the Khan study [59].
Dr. John Schoeffel, inventor and royalty recipient (SybronEndo/Kerr Endodontics) of the EndoVac system, originally envisioned the concept of NaOCl traveling in the venous system after scrutinizing the Bradford study [68] and the associated references. I am grateful for his help in explaining the concept of intraosseous fluid delivery and the intracanal fluid dynamics that affect periapical pressure as well as his assistance in organizing the logic path and graphics for this chapter.
Dr. Ovidiu Cioanu (www.ovidiu.ca) produced graphics 4 B and C.
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Glassman, G. (2015). Complications of Endodontic Irrigation: Dental, Medical, and Legal. In: Basrani, B. (eds) Endodontic Irrigation. Springer, Cham. https://doi.org/10.1007/978-3-319-16456-4_6
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DOI: https://doi.org/10.1007/978-3-319-16456-4_6
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