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Head and Neck

  • Chapter
Survivors of Childhood and Adolescent Cancer

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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Abstract

Most head and neck neoplasms require a combination of chemotherapy and radiation therapy for cure as their anatomic location makes local control by surgical resection difficult. Approximately 40 % of rhabdomyosarcomas arise in this region. Ewing sarcoma, osteosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, nasopharyngeal carcinoma, lymphoma, neuroblastoma, hemangioma, and histiocytosis also occur in the head and neck. However, the head and neck region is composed of multiple sensitive tissues, including the major organs for sensation (eyes, ears, nose, and mouth), mucous membranes, salivary glands, teeth, larynx, pharynx, skull base, and associated regions of the brain and the hypothalamic-pituitary axis, in which treatment-related toxicity can be associated with significant acute and long-term morbidity. The current chapter reviews the pathophysiology and clinical manifestations of the late effects in the head and neck region, outlines methods for screening and detection, and suggests interventions that can be used in their management.

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Authors and Affiliations

  1. Division of Pediatric Hematology/Oncology, Department of Pediatrics, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX, USA

    Chrystal U. Louis MD & Arnold C. Paulino MD

  2. Department of Radiation Oncology, MD Anderson Cancer Center, 1515 Holcombe Blvd., 97, Houston, TX, 77030, USA

    Arnold C. Paulino MD

Authors
  1. Chrystal U. Louis MD
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  2. Arnold C. Paulino MD
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Correspondence to Arnold C. Paulino MD .

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Editors and Affiliations

  1. Department of Pediatrics, MD Anderson Cancer Center, Houston, Texas, USA

    Cindy L. Schwartz

  2. Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Wendy L. Hobbie

  3. Departments of Radiation Oncology and Pediatrics, University of Rochester Medical Center, James P. Wilmot Cancer Ctr, Rochester, New York, USA

    Louis S. Constine

  4. Center for Cancer And Blood Diseases, Children's Hospital Los Angeles, Los Angeles, California, USA

    Kathleen S. Ruccione

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Louis, C.U., Paulino, A.C. (2015). Head and Neck. In: Schwartz, C., Hobbie, W., Constine, L., Ruccione, K. (eds) Survivors of Childhood and Adolescent Cancer. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-16435-9_7

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  • DOI: https://doi.org/10.1007/978-3-319-16435-9_7

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