Abstract
Results presented in this chapter were originally published in the journal article: “Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. RNA Biology 10, 1146-1159”. This article can be accessed at:
Results presented in this chapter were originally published in the journal article: “Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. RNA Biology 10, 1146-1159”. This article can be accessed at:
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Anders G, Mackowiak SD, Jens M, Maaskola J, Kuntzagk A, Rajewsky N, Landthaler M, Dieterich C (2012) doRiNA: a database of RNA interactions in post-transcriptional regulation. Nucleic Acids Res 40:D180–D186
Bailey TL, Boden M, Buske FA, Frith M, Grant CE, Clementi L, Ren J, Li WW, Noble WS (2009) MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res 37:W202–W208
Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M et al (2012) The mRNAbound proteome and its global occupancy profile on protein-coding transcripts. Mol Cell 46:674–690
Cho J, Chang H, Kwon SC, Kim B, Kim Y, Choe J, Ha M, Kim YK, Kim VN (2012) LIN28A is a suppressor of ER-associated translation in embryonic stem cells. Cell 151:765–777
Desjardins A, Yang A, Bouvette J, Omichinski JG, Legault P (2012) Importance of the NCp7-like domain in the recognition of pre-let-7 g by the pluripotency factor Lin28. Nucleic Acids Res 40:1767–1777
Graf R, Munschauer M, Mastrobuoni G, Mayr F, Heinemann U, Kempa S, Rajewsky N, Landthaler M (2013) Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. RNA Biol 10:1146–1159
Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp A-C, Munschauer M et al (2010) Transcriptome-wide identification of RNA-binding protein and MicroRNA target sites by PAR-CLIP. Cell 141:129–141
Kishore S, Jaskiewicz L, Burger L, Hausser J, Khorshid M, Zavolan M (2011) A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods 8:559–564
Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M et al (2005) Combinatorial microRNA target predictions. Nat Genet 37:495–500
Lebedeva S, Jens M, Theil K, Schwanhäusser B, Selbach M, Landthaler M, Rajewsky N (2011) transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell 43:340–352
Lei XX, Xu J, Ma W, Qiao C, Newman MA, Hammond SM, Huang Y (2012) Determinants of mRNA recognition and translation regulation by Lin28. Nucleic Acids Res 40:3574–3584
Loughlin FE, Gebert LFR, Towbin H, Brunschweiger A, Hall J, Allain FH-T (2012) Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28. Nat Struct Mol Biol 19:84–89
Mayr F, Schütz A, Döge N, Heinemann U (2012) The Lin28 cold-shock domain remodels pre-let-7 microRNA. Nucleic Acids Res 40:7492–7506
Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P (2011) Molecular basis for interaction of let-7 microRNAs with Lin28. Cell 147:1080–1091
Peng S, Chen L-L, Lei X-X, Yang L, Lin H, Carmichael GG, Huang Y (2011) Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem Cells 29:496–504
Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss EG, Harel-Bellan A (2007) Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev 21:1125–1138
Schwanhäusser B, Gossen M, Dittmar G, Selbach M (2009) Global analysis of cellular protein translation by pulsed SILAC. Proteomics 9:205–209
Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455:58–63
Thornton JE, Gregory RI (2012) How does Lin28 let-7 control development and disease? Trends Cell Biol 1–9
Xu B, Huang Y (2009) Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element. Nucleic Acids Res 37:4256–4263
Zhang C, Darnell RB (2011) Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat Biotechnol 29:607–614
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Munschauer, M. (2015). Mapping Regulatory Interactions of the RNA-Binding Protein LIN28B. In: High-Resolution Profiling of Protein-RNA Interactions. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-16253-9_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-16253-9_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-16252-2
Online ISBN: 978-3-319-16253-9
eBook Packages: EngineeringEngineering (R0)