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Lung Stem Cells in the Epithelium and Vasculature pp 203–219Cite as

Lung Microvascular Endothelium as a Putative Progenitor Cell Niche

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Endothelium is formed by a contiguous network of cells that separate the circulation from the underlying tissue. Cells within the endothelial network collaborate to relay chemical and mechanical signals between blood and tissue. Each of these cells is highly specialized. Such specialization is seen in endothelial cell growth, where some cells are highly proliferative, others less so, and some display no growth potential at all. The highly replication competent cells fulfill the criteria of a “progenitor.” Progenitor cells have important implications for vascular maintenance and for vascular repair following injury. This chapter examines the current state of knowledge regarding endothelial cell progenitor cells found within lung capillaries and identifies knowledge gaps within the field that are ongoing areas of research.

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Author information

Authors and Affiliations

  1. Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL, 36688, USA

    Lauren Hartman & Troy Stevens Ph.D.

  2. Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    Lauren Hartman & Troy Stevens Ph.D.

  3. Department of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    Troy Stevens Ph.D.

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  1. Lauren Hartman
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  2. Troy Stevens Ph.D.
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Correspondence to Troy Stevens Ph.D. .

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Editors and Affiliations

  1. Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, USA

    Amy Firth

  2. Department of Medicine, The Univsersity of Arizona, Tucson, Arizona, USA

    Jason X.-J. Yuan

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Hartman, L., Stevens, T. (2015). Lung Microvascular Endothelium as a Putative Progenitor Cell Niche. In: Firth, A., Yuan, JJ. (eds) Lung Stem Cells in the Epithelium and Vasculature. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-16232-4_11

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