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Regulation of Actin-Based Structure Dynamics by HspB Proteins and Partners

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Book cover The Big Book on Small Heat Shock Proteins

Part of the book series: Heat Shock Proteins ((HESP,volume 8))

Abstract

Small heat shock proteins (HspB proteins) form a diverse family of proteins that have evolved distinct modes of action to protect cells from proteotoxic stress. Studies conducted within the last 25 years have revealed specialized roles for some HspB, in particular for HspB1, HspB8, and its cochaperone Bag3, in the modulation of actin-based cytoskeletal dynamics under physiological and stress conditions, which might be related to their linkage to human cancer. Little is known, however, on whether and how such biological activities on signaling are connected to pathways within the quality control network. In this chapter, we examine functional relationships between HspB proteins, the cochaperone Bag3 and actin dynamics and describe the mechanisms known so far that are responsible for their modulation of actin architecture. We further discuss on how such activities might be connected to quality control network. While some pieces of the puzzle might need to be inserted differently, we hope that this review will stimulate further studies to elucidate the mechanistic behind chaperone-mediated actin remodeling by HspB proteins and their partners.

Solenn M. Guilbert, Alice-Anaïs Varlet are co-first authors.

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Acknowledgments

This work was supported by the Canadian Institutes of Health Research (Grant number 7088 to JNL and JL).

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Authors and Affiliations

  1. Centre de recherche sur le cancer de l’Université Laval, Quebec, QC, Canada

    Solenn M. Guilbert, Alice-Anaïs Varlet, Margit Fuchs, Herman Lambert, Jacques Landry & Josée N. Lavoie

  2. Centre de recherche du Centre Hospitalier Universitaire de Québec, Axe Oncologie, Quebec, QC, Canada

    Solenn M. Guilbert, Alice-Anaïs Varlet, Margit Fuchs, Herman Lambert, Jacques Landry & Josée N. Lavoie

  3. Groupe St-Patrick de recherche en Oncologie Fondamentale, Quebec, QC, Canada

    Solenn M. Guilbert, Alice-Anaïs Varlet, Margit Fuchs, Herman Lambert, Jacques Landry & Josée N. Lavoie

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  1. Solenn M. Guilbert
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  2. Alice-Anaïs Varlet
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  3. Margit Fuchs
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  4. Herman Lambert
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Correspondence to Josée N. Lavoie .

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  1. Department of Molecular Biology, Medical Biochemistry & Pathology Medical School Lab Cell & Developmental Genetics IBIS, Université Laval, Quebec, Québec, Canada

    Robert M. Tanguay

  2. Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA

    Lawrence E. Hightower

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Guilbert, S.M., Varlet, AA., Fuchs, M., Lambert, H., Landry, J., Lavoie, J.N. (2015). Regulation of Actin-Based Structure Dynamics by HspB Proteins and Partners. In: Tanguay, R., Hightower, L. (eds) The Big Book on Small Heat Shock Proteins. Heat Shock Proteins, vol 8. Springer, Cham. https://doi.org/10.1007/978-3-319-16077-1_18

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