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The Dynamic Duo of Small Heat Proteins and IFs Maintain Cell Homeostasis, Resist Cellular Stress and Enable Evolution in Cells and Tissues

  • Chapter
The Big Book on Small Heat Shock Proteins

Part of the book series: Heat Shock Proteins ((HESP,volume 8))

Abstract

As with many proteins, their initial christening with a name corrals our thinking on their functions and roles. IFs were not named as heat shock proteins, but along with heat shock proteins, they continue to be expressed in response to heat shock. In this review we outline the case for exposing the identity of the “dynamic duo” as small heat shock proteins (sHSPs) and their IF (IF) partners in their battle to assuage stress. Together they maintain the homeostasis of and integrate key cellular processes within cells that allow potential evolutionary opportunity to be seized (Quinlan RA, Ellis RJ, Philos Trans R Soc Lond B Biol Sci 368:20130091, 2013). Both sHSPs and IFs form dynamic polymeric structures – nano-particles and intermediate (nano) filaments respectively. Both have a wide range of interaction (client) proteins. IFs provide a convenient matrix to host small heat shock proteins and potentiate their role as chaperones, whilst IF function is sHSP-dependent. Together, it is their emerging capacity as integrators of both cell homeostasis and the stress response within and between tissues, however, which is the most exciting. This is because the dynamic duo co-operate on the two central chaperone activities – assisting protein assemblies and dealing with the consequences of protein damage. We propose that the sHSP-IF partnership is key to understanding the stress response, not least because it emphasizes the role of these protein chaperones in assisting the building, regulation and turnover of the IF protein assemblies as well as in diseases caused by their malfunction.

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Abbreviations

CRYAB:

αB-crystallin

DRM:

Desmin related myopathy

GFAP:

Glial fibrillary acidic protein

HSP:

Heat shock protein

HSR:

Heat shock response

IF:

Intermediate filament

NF-L:

Neurofilament light chain

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Acknowledgements

The financial support of the National Science Council to MDP is gratefully acknowledged. RAQ thanks the financial support of the Leverhulme Trust (RPG-2012-554).

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  1. Institute of Molecular Medicine, College of Life Sciences, National Tsing Hua University, Hsinchu, 300, Taiwan

    Ming Der Perng

  2. Biophysical Sciences Institute, University of Durham, South Road, Durham, DH1 3LE, UK

    Roy A. Quinlan

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Correspondence to Ming Der Perng .

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  1. Department of Molecular Biology, Medical Biochemistry & Pathology Medical School Lab Cell & Developmental Genetics IBIS, Université Laval, Quebec, Québec, Canada

    Robert M. Tanguay

  2. Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA

    Lawrence E. Hightower

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Der Perng, M., Quinlan, R.A. (2015). The Dynamic Duo of Small Heat Proteins and IFs Maintain Cell Homeostasis, Resist Cellular Stress and Enable Evolution in Cells and Tissues. In: Tanguay, R., Hightower, L. (eds) The Big Book on Small Heat Shock Proteins. Heat Shock Proteins, vol 8. Springer, Cham. https://doi.org/10.1007/978-3-319-16077-1_17

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