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Sympathetic Nervous System Signaling in Heart Failure and Cardiac Aging

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Book cover Pathophysiology and Pharmacotherapy of Cardiovascular Disease

Abstract

Heart failure represents the leading cause of death, especially among the elderly. Despite the development of numerous therapeutic strategies, heart failure prevalence is still increasing. Ergo, exploring the molecular mechanisms underlying aging-related heart failure seems to be of particular relevance. Intriguingly, the fields of cardiovascular disease and aging, which have remained largely separate hitherto, seem to have a common point in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disease. This chapter will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiac aging.

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Authors and Affiliations

  1. Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy

    Gaetano Santulli MD, PhD

  2. College of Physicians and Surgeons, Columbia University Medical Center, Russ Berrie Medical Pavilion, 1150 St Nicholas Ave, Suite 513, New York, NY, 10032, USA

    Gaetano Santulli MD, PhD

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  1. Center for Drug Evaluation and Research Division of Cardiovascular and Renal Products, US Food and Drug Administration, Silver Spring, Maryland, USA

    Gowraganahalli Jagadeesh

  2. Pharmacology Unit, AIMST University, Bedong, Malaysia

    Pitchai Balakumar

  3. Center for Drug Evaluation and Research Division of Cardiovascular and Renal Products, US Food and Drug Administration, Silver Spring, Maryland, USA

    Khin Maung-U

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Santulli, G. (2015). Sympathetic Nervous System Signaling in Heart Failure and Cardiac Aging. In: Jagadeesh, G., Balakumar, P., Maung-U, K. (eds) Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Adis, Cham. https://doi.org/10.1007/978-3-319-15961-4_5

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